(R)-3-(naphthalen-2-yloxy)propane-1,2-diol

Base Information

• Chemical Name: (R)-3-(naphthalen-2-yloxy)propane-1,2-diol
• CAS No.: 205306-84-9
• Molecular Formula: C₁₃H₁₄O₃
• Molecular Weight: 218.252
• Mol file: 205306-84-9.mol

Synonyms:(R)-3-(naphthalen-2-yloxy)propane-1,2-diol

Chemical Property of (R)-3-(naphthalen-2-yloxy)propane-1,2-diol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-(naphthalen-2-yloxy)propane-1,2-diol

There total 3 articles about (R)-3-(naphthalen-2-yloxy)propane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

[(2-naphthalenyloxy)methyl]oxirane (5234-06-0) → (S)-3-(naphthalen-2-yloxy)propane-1,2-diol (912284-00-5) + (R)-3-(naphthalen-2-yloxy)propane-1,2-diol (205306-84-9) + (S)-(-)-3-(2'-naphthyloxy)-1,2-epoxypropane (5234-06-0,128994-02-5,129098-62-0,129098-61-9)

Guidance literature:

With water; In dichloromethane; acetonitrile; at 0 - 20 ℃; for 60h; Resolution of racemate;

DOI:10.1021/ja302340b

Reference yield:

[(2-naphthalenyloxy)methyl]oxirane (5234-06-0) → (R)-3-(naphthalen-2-yloxy)propane-1,2-diol (205306-84-9) + (S)-(-)-3-(2'-naphthyloxy)-1,2-epoxypropane (5234-06-0,128994-02-5,129098-62-0,129098-61-9)

Guidance literature:

With 5CF₃O₃S^(1-)*2Co⁽³⁺⁾*Y⁽³⁺⁾*2C₃₆H₅₂N₂O₂^(2-); water; In tetrahydrofuran; at 20 ℃; for 24h; Overall yield = 46 %; enantioselective reaction;

DOI:10.1039/c5ra12408e

Reference yield:

[(2-naphthalenyloxy)methyl]oxirane (5234-06-0) → (R)-3-(naphthalen-2-yloxy)propane-1,2-diol (205306-84-9) + (S)-(-)-3-(2'-naphthyloxy)-1,2-epoxypropane (5234-06-0,128994-02-5,129098-62-0,129098-61-9) + 3-(2-naphthyloxy)-1,2-epoxypropane (129098-62-0)

Guidance literature:

With 4CF₃O₃S^(1-)*Co⁽³⁺⁾*Y⁽³⁺⁾*C₃₆H₅₂N₂O₂^(2-); water; In tetrahydrofuran; at 20 ℃; for 48h; Overall yield = 10 %; enantioselective reaction;

DOI:10.1039/c5ra12408e

upstream raw materials:

[(2-naphthalenyloxy)methyl]oxirane

Refernces

• 1、 Zhu, Chengfeng,Yuan, Guozan,Chen, Xu,Yang, Zhiwei,Cui, Yong. "Chiral nanoporous metal-metallosalen frameworks for hydrolytic kinetic resolution of epoxides". supporting information; experimental part. p. 8058 - 8061. Retrieved 2012/07/14.