C₂₀H₁₉NO₅S

Base Information

• Chemical Name: C₂₀H₁₉NO₅S
• CAS No.: 1502873-99-5
• Molecular Formula: C₂₀H₁₉NO₅S
• Molecular Weight: 385.441
• Mol file: 1502873-99-5.mol

Synonyms:C₂₀H₁₉NO₅S

Chemical Property of C₂₀H₁₉NO₅S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₁₉NO₅S

There total 6 articles about C₂₀H₁₉NO₅S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(benzhydrylthio)acetic acid (63547-22-8) → C20H19NO5S (1502873-99-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: thionyl chloride / benzene / 1 h / Inert atmosphere; Reflux

2.1: ammonium hydroxide / water; dichloromethane / 1 h / 0 °C

3.1: dihydrogen peroxide / water; acetic acid / 4 h / Cooling

4.1: lithium tert-butoxide / dichloromethane; acetonitrile; hexane / 0.42 h / 0 - 20 °C

4.2: 0 - 20 °C

With ammonium hydroxide; thionyl chloride; dihydrogen peroxide; lithium tert-butoxide; In hexane; dichloromethane; water; acetic acid; acetonitrile; benzene;

Reference yield:

methyl (E)-4-chloro-4-oxo-2-butenoate (17081-97-9) + Modafinil (112111-43-0,112111-47-4,112111-49-6,68693-11-8) → C20H19NO5S (1502873-99-5)

Guidance literature:

Modafinil; With lithium tert-butoxide; In hexane; dichloromethane; acetonitrile; at 0 - 20 ℃; for 0.416667h;

methyl (E)-4-chloro-4-oxo-2-butenoate; In hexane; dichloromethane; acetonitrile; at 0 - 20 ℃;

Reference yield:

methyl hydrogen fumarate (2756-87-8) → C20H19NO5S (1502873-99-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2.1: lithium tert-butoxide / dichloromethane; acetonitrile; hexane / 0.42 h / 0 - 20 °C

2.2: 0 - 20 °C

With oxalyl dichloride; N,N-dimethyl-formamide; lithium tert-butoxide; In hexane; dichloromethane; acetonitrile;

upstream raw materials:

methyl hydrogen fumarate

methyl (E)-4-chloro-4-oxo-2-butenoate

Modafinil

Bromodiphenylmethane

Downstream raw materials:

C₁₉H₁₇NO₅S

Refernces

• 1、 -. "COMPOSITIONS AND METHODS FOR TREATMENT OF NEUROLOGICAL DEGENERATIVE DISORDERS AND NEUROLOGICAL DISEASES". . . Retrieved 2014/01/07.