3-Pyridinecarbonyl chloride, 4-chloro- (9CI)

Base Information

• Chemical Name: 3-Pyridinecarbonyl chloride, 4-chloro- (9CI)
• CAS No.: 100791-00-2
• Molecular Formula: C6H3 Cl2 N O
• Molecular Weight: 176.002
• Hs Code.: 2933399090
• Mol file: 100791-00-2.mol

Synonyms:4-Chloro-3-pyridinecarbonylchloride; 4-Chloronicotinoyl chloride

Chemical Property of 3-Pyridinecarbonyl chloride, 4-chloro- (9CI)

Chemical Property:

• PSA: 29.96000
• LogP: 2.11400

Purity/Quality:

98%min ^*data from raw suppliers

4-Chloronicotinoyl chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarbonyl chloride, 4-chloro- (9CI)

There total 1 articles about 3-Pyridinecarbonyl chloride, 4-chloro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.5%

4-chloronicotinic acid (10177-29-4) → 4-chloronicotinoyl chloride (100791-00-2)

Guidance literature:

With thionyl chloride; at 80 ℃; for 1.5h;

Reference yield: 91.0%

4-chloronicotinoyl chloride (100791-00-2) + (S)-2-(azidodiphenylmethyl)pyrrolidine (1227182-01-5) → (S)-(2-(azidodiphenylmethyl)pyrrolidin-1-yl)(4-chloropyridin-3-yl)methanone

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16.16h; Inert atmosphere;

DOI:10.1055/s-0033-1339286

Reference yield: 86.0%

4-chloronicotinoyl chloride (100791-00-2) + C15H20N4S → C21H22ClN5OS

Guidance literature:

With triethylamine; In dichloromethane; at 10 - 20 ℃; for 10h;

upstream raw materials:

4-chloronicotinic acid

Downstream raw materials:

1-phenylpyrazolo[4',3':5,6]pyrano[3,2-c]pyridin-4(1H)-one

3-methyl-1-phenylpyrazolo[4',3':5,6]pyrano[3,2-c]pyridin-4(1H)-one

4-chloro-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-nicotinanilide

ethyl 4-phenoxynicotinate

Refernces

• 1、 Zhan, Gu,Shi, Ming-Lin,He, Qing,Lin, Wei-Jia,Ouyang, Qin,Du, Wei,Chen, Ying-Chun. "Catalyst-controlled switch in chemo- and diastereoselectivities: Annulations of morita-baylis-hillman carbonates from isatins". . p. 2147 - 2151. Retrieved 2016.
• 2、 -. "HINDERED DISULFIDE DRUG CONJUGATES". Page/Page column 127; 142; 143. . Retrieved 2017/05/02.