5-Bromo-2-methyl-4-pyrimidinecarboxylic acid

Base Information

• Chemical Name: 5-Bromo-2-methyl-4-pyrimidinecarboxylic acid
• CAS No.: 100707-39-9
• Molecular Formula: C6H5BrN2O2
• Molecular Weight: 217.022
• Hs Code.: 2933599090
• Mol file: 100707-39-9.mol

Synonyms:2-Methyl-5-bromopyrimidine-4-carboxylicacid;NSC 82651;

Chemical Property of 5-Bromo-2-methyl-4-pyrimidinecarboxylic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 172-173 °C (decomp)(Solv: methanol (67-56-1))
• Refractive Index: 1.61
• Boiling Point: 335.169 °C at 760 mmHg
• PKA: 1.53±0.10(Predicted)
• Flash Point: 156.505 °C
• PSA: 63.08000
• Density: 1.795 g/cm³
• LogP: 1.24570
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Methyl-5-bromopyrimidine-4-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-2-methyl-4-pyrimidinecarboxylic acid

There total 4 articles about 5-Bromo-2-methyl-4-pyrimidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

mucobromic acid (766-38-1) + acetamidine hydrochloride (124-42-5) → 5-bromo-2-methyl-pyrimidine-4-carboxylic acid (100707-39-9)

Guidance literature:

acetamidine hydrochloride; With sodium ethanolate; In ethanol; at 50 ℃;

mucobromic acid; With sodium ethanolate; In ethanol;

Reference yield: 25.2%

(2E)-2,3-dibromo-4-oxobut-2-enoic acid (90994-06-2) + acetamidine hydrochloride (124-42-5) → 5-bromo-2-methyl-pyrimidine-4-carboxylic acid (100707-39-9)

Guidance literature:

With sodium ethanolate; In ethanol; at 20 - 50 ℃; for 17h;

Reference yield:

mucobromic acid (488-11-9) + acetamidine hydrochloride (124-42-5) → 5-bromo-2-methyl-pyrimidine-4-carboxylic acid (100707-39-9)

Guidance literature:

With sodium ethanolate;

upstream raw materials:

mucobromic acid

acetamidine hydrochloride

mucobromic acid

(2E)-2,3-dibromo-4-oxobut-2-enoic acid

Downstream raw materials:

5-Bromo-2-methyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide

2-Methyl-5-phenyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide

5-methoxy-2-methylpyrimidine-4-carboxylic acid

5-bromo-2-methylpyrimidine

Refernces

• 1、 -. "PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH ZINC BINDING MOIETY". Paragraph 0319. . Retrieved 2016/10/07.
• 2、 -. "TREATMENT OF CANCERS HAVING K-RAS MUTATIONS". Paragraph 0364; 0365. . Retrieved 2013/05/08.