5-Amino-3-(4-chlorophenyl)-1,2,4-thiadiazole

Base Information

• Chemical Name: 5-Amino-3-(4-chlorophenyl)-1,2,4-thiadiazole
• CAS No.: 19922-07-7
• Molecular Formula: C₈H₆ClN₃S
• Molecular Weight: 211.675
• Hs Code.: 2934999090
• Mol file: 19922-07-7.mol

Synonyms:1,2,4-Thiadiazole,5-amino-3-(p-chlorophenyl)- (6CI,8CI);

Chemical Property of 5-Amino-3-(4-chlorophenyl)-1,2,4-thiadiazole

Chemical Property:

• Vapor Pressure: 4.26E-06mmHg at 25°C
• Melting Point: 183-185℃
• Refractive Index: 1.676
• Boiling Point: 383.9 °C at 760 mmHg
• PKA: 2.68±0.36(Predicted)
• Flash Point: 186 °C
• PSA: 80.04000
• Density: 1.461 g/cm³
• LogP: 3.02190

Purity/Quality:

98%min ^*data from raw suppliers

3-(4-chlorophenyl)-1,2,4-thiadiazol-5-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Amino-3-(4-chlorophenyl)-1,2,4-thiadiazole

There total 4 articles about 5-Amino-3-(4-chlorophenyl)-1,2,4-thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C8H8ClN3S → 3-(p-chlorophenyl)-1,2,4-thiadiazol-5-amine (19922-07-7)

Guidance literature:

With iodine; In water; dimethyl sulfoxide; at 25 ℃; for 10h; Sealed tube; Schlenk technique; Green chemistry;

DOI:10.1002/ejoc.201800670

Reference yield:

4-chlorobenzimidic acid ethyl ester (827-72-5) → 3-(p-chlorophenyl)-1,2,4-thiadiazol-5-amine (19922-07-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / dimethyl sulfoxide / 4 h / 25 °C / Sealed tube; Schlenk technique

2: iodine / dimethyl sulfoxide; water / 10 h / 25 °C / Sealed tube; Schlenk technique; Green chemistry

With potassium tert-butylate; iodine; In water; dimethyl sulfoxide;

DOI:10.1002/ejoc.201800670

Reference yield:

potassium thioacyanate (333-20-0) + 4-chlorobenzamidine hydrochloride (14401-51-5) → 3-(p-chlorophenyl)-1,2,4-thiadiazol-5-amine (19922-07-7)

Guidance literature:

With bromine; sodium methylate; In methanol;

upstream raw materials:

N-bromo-4-chloro-benzamidine

potassium thioacyanate

4-chlorobenzamidine hydrochloride

4-chlorobenzimidic acid ethyl ester

Downstream raw materials:

3-(4-chloro-phenyl)-5-(2,4,6-trimethyl-phenylazo)-[1,2,4]thiadiazole

Refernces