N2-METHYL-2'-DEOXYGUANOSINE

Base Information

• Chemical Name: N2-METHYL-2'-DEOXYGUANOSINE
• CAS No.: 19916-77-9
• Molecular Formula: C₁₁H₁₅N₅O₄
• Molecular Weight: 281.271
• Mol file: 19916-77-9.mol

Synonyms:2'-Deoxy-N-methylguanosine;N2-Methyl-2'-deoxyguanosine

Chemical Property of N2-METHYL-2'-DEOXYGUANOSINE

Chemical Property:

• PKA: 9.87±0.20(Predicted)
• PSA: 125.29000
• Density: 1.85±0.1 g/cm3(Predicted)
• LogP: -1.12500
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly, Sonicated)

Purity/Quality:

98%Min ^*data from raw suppliers

N2-Methyl-2’-deoxyguanosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N2-Methyl-2’-deoxyguanosine is a product from the reaction of formaldehyde with exocyclic amino group of deoxyguanosine. Used as the template in primer extension reactions catalyzed by the Klenow fragment of Escherichia coli DNA polymerase I.

Technology Process of N2-METHYL-2'-DEOXYGUANOSINE

There total 2 articles about N2-METHYL-2'-DEOXYGUANOSINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

2-fluoro-O6-(2-(p-nitrophenyl)ethyl)-2'-deoxyinosine (132183-39-2) + methylamine (74-89-5) → 2'-deoxy-2-N-methylguanosine (19916-77-9)

Guidance literature:

In water; at 60 ℃;

DOI:10.1039/a700366h

Reference yield:

→ 2'-deoxy-2-N-methylguanosine (19916-77-9)

Guidance literature:

2-Methylamino-6-benzyloxy-9-(2-desoxy-β-D-erythro-pentofuranosyl)-purin, H2, Pd-C;

DOI:10.1021/jo01259a029

upstream raw materials:

2-fluoro-O⁶-(2-(p-nitrophenyl)ethyl)-2'-deoxyinosine

methylamine

Refernces