Piperidin-2-ylacetic acid

Base Information

• Chemical Name: Piperidin-2-ylacetic acid
• CAS No.: 19832-04-3
• Molecular Formula: C7H13 N O2
• Molecular Weight: 143.186
• Hs Code.: 2933399090
• European Community (EC) Number: 631-552-6
• DSSTox Substance ID: DTXSID00390377
• Mol file: 19832-04-3.mol

Synonyms:19832-04-3;2-Piperidylacetic Acid;piperidin-2-ylacetic acid;2-piperidine acetic acid;2-(piperidin-2-yl)acetic acid;2-Piperidineacetic acid;Piperidin-2-yl-acetic acid;2-piperidin-2-ylacetic acid;2-piperidinylacetic acid;MFCD02667638;(2S)-2-PIPERIDINEACETIC ACID;2-(2-piperidyl)acetic acid;2-PiperidylaceticAcid;dodecylisothiocyanate;(R)-Homopipecolicacid;piperidine-2-acetic acid;MLS000716966;SCHEMBL644279;DTXSID00390377;2-Pyridineacetic acid, hexahydro-;HMS1698G08;AC1464;STK499947;AKOS000321358;AKOS016050397;AC-7381;MB07045;SB41330;SB47294;AS-59770;SMR000278483;SY005973;(R)-2-Piperidineacetic acid hydrochloride;(S)-2-Piperidineacetic acid hydrochloride;BB 0240554;CS-0096283;FT-0677811;EN300-50511;A852937

Chemical Property of Piperidin-2-ylacetic acid

Chemical Property:

• Vapor Pressure: 0.000659mmHg at 25°C
• Refractive Index: 1.465
• Boiling Point: 286.8°Cat760mmHg
• Flash Point: 127.3°C
• PSA: 49.33000
• Density: 1.063g/cm³
• LogP: 0.93200
• XLogP3: -2.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 143.094628657
• Heavy Atom Count: 10
• Complexity: 125

Purity/Quality:

98%min ^*data from raw suppliers

2-PiperidylaceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCNC(C1)CC(=O)O

Technology Process of Piperidin-2-ylacetic acid

There total 31 articles about Piperidin-2-ylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(R)-2-[(N-benzyloxycarbonyl)piperidin-2-yl]ethanoic acid (1036403-99-2,137428-09-2) → (R)-2-(piperidin-2'-yl)ethanoic acid (19832-04-3,55049-18-8,64625-19-0,69222-96-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 16h; under 760.051 Torr;

DOI:10.1021/jo800749t

Reference yield: 99.0%

2-ethoxycarbonylmethylpiperidine (2739-99-3) → 2-(piperidin-2-yl)acetic acid (19832-04-3)

Guidance literature:

With water;

DOI:10.1016/S0040-4039(00)82237-6

Reference yield: 90.6%

N-Camphanoylhomopipecolinsaeure (111504-88-2) → (R)-2-(piperidin-2'-yl)ethanoic acid (19832-04-3,55049-18-8,64625-19-0,69222-96-4)

Guidance literature:

With sulfuric acid; at 95 ℃; for 4h;

upstream raw materials:

2(RS)-(2-hydroxyethyl)piperidine

5-(N-benzyloxycarbonylamino)pentanoic acid

Tripiperidin

malonic acid

Downstream raw materials:

(R)-2-(1-(tert-butoxycarbonyl)piperidin-2-yl) acetic acid

2-(1-(tert-butoxycarbonyl)piperidin-2-yl)acetic acid

(R)-2-[(N-benzyloxycarbonyl)piperidin-2-yl]ethanoic acid

C₁₆H₁₅F₆NO₃

Refernces

• 1、 Good et al.. "-". . p. 609. Retrieved 1972.
• 2、 -. "Histamine H3 Inverse Agonists and Antagonists and Methods of Use Thereof". Page/Page column 59. . Retrieved 2011/04/18.
• 3、 Davies, Stephen G.,Fletcher, Ai M.,Roberts, Paul M.,Smith, Andrew D.. "Asymmetric synthesis of Sedum alkaloids via lithium amide conjugate addition". experimental part. p. 10192 - 10213. Retrieved 2010/02/28.