1′-(2-nitrophenyl)spiro[cyclohexane-1,3′-indoline]

Base Information

• Chemical Name: 1′-(2-nitrophenyl)spiro[cyclohexane-1,3′-indoline]
• CAS No.: 870072-67-6
• Molecular Formula: C₁₉H₂₂N₂
• Molecular Weight: 278.397
• Mol file: 870072-67-6.mol

Synonyms:1′-(2-nitrophenyl)spiro[cyclohexane-1,3′-indoline]

Chemical Property of 1′-(2-nitrophenyl)spiro[cyclohexane-1,3′-indoline]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1′-(2-nitrophenyl)spiro[cyclohexane-1,3′-indoline]

There total 6 articles about 1′-(2-nitrophenyl)spiro[cyclohexane-1,3′-indoline] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1′-(2-nitrophenyl)spiro[cyclohexane-1,3′-indoline] (870072-66-5) → 1′-(2-nitrophenyl)spiro[cyclohexane-1,3′-indoline] (870072-67-6)

Guidance literature:

With tin(ll) chloride; In ethyl acetate; at 20 ℃; for 16h;

Reference yield: 80.0%

1′-(2-nitrophenyl)spiro[cyclohexane-1,3′-indoline] (870072-66-5) + ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → 1′-(2-nitrophenyl)spiro[cyclohexane-1,3′-indoline] (870072-67-6)

Guidance literature:

With tin(II) chloride dihdyrate; In ethyl acetate; at 23 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jm4013906

Reference yield:

2-oxoindole (59-48-3) → 1′-(2-nitrophenyl)spiro[cyclohexane-1,3′-indoline] (870072-67-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -74 - -50 °C / Inert atmosphere

1.2: 10 h / 20 °C / Inert atmosphere; Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 23 °C / Inert atmosphere; Reflux

3.1: neat (no solvent) / 8 h / 175 °C / Inert atmosphere; Microwave irradiation; Sealed tube

4.1: tin(II) chloride dihdyrate / ethyl acetate / 16 h / 23 °C / Inert atmosphere

With lithium aluminium tetrahydride; tin(II) chloride dihdyrate; lithium hexamethyldisilazane; In tetrahydrofuran; ethyl acetate;

DOI:10.1021/jm4013906

upstream raw materials:

1′-(2-nitrophenyl)spiro[cyclohexane-1,3′-indoline]

2-oxoindole

1,5-dibromo-pentane

ortho-nitrofluorobenzene

Refernces

• 1、 -. "Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions". Page/Page column 53. . Retrieved 2008/06/13.