3-(Z-Gly)-pyridyl ester

Base Information

• Chemical Name: 3-(Z-Gly)-pyridyl ester
• CAS No.: 2778-21-4
• Molecular Formula: C₁₅H₁₄N₂O₄
• Molecular Weight: 286.287
• Mol file: 2778-21-4.mol

Synonyms:3-(Z-Gly)-pyridyl ester

Chemical Property of 3-(Z-Gly)-pyridyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 3-(Z-Gly)-pyridyl ester

There total 1 articles about 3-(Z-Gly)-pyridyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-HYDROXYPYRIDINE (109-00-2) + N-(Benzyloxycarbonyl)glycine (1138-80-3) → 3-(Z-Gly)-pyridyl ester (2778-21-4)

Guidance literature:

With dicyclohexyl-carbodiimide; Yield given. Multistep reaction; 1, 2) DMF;

DOI:10.1248/cpb.39.584

Reference yield: 66.0%

3-(Z-Gly)-pyridyl ester (2778-21-4) + L-proline (147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → (2S)-1-(2-[[(benzyloxy)carbonyl]amino]acetyl)tetrahydro-1H-pyrrole-2-carboxylic acid (1160-54-9)

Guidance literature:

With triethylamine; In water; N,N-dimethyl-formamide;

DOI:10.1248/cpb.39.584

Reference yield:

3-(Z-Gly)-pyridyl ester (2778-21-4) → Z-Gly-Pro-Arg(NO2)-piperidine (134303-79-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / Et₃N / H₂O; dimethylformamide

2: 52 percent / mixed anhydride method

With triethylamine; In water; N,N-dimethyl-formamide;

DOI:10.1248/cpb.39.584

upstream raw materials:

3-HYDROXYPYRIDINE

N-(Benzyloxycarbonyl)glycine

Downstream raw materials:

(2S)-1-(2-[[(benzyloxy)carbonyl]amino]acetyl)tetrahydro-1H-pyrrole-2-carboxylic acid

N-Benzyloxycarbonyl-glycyl-DL-phenylalanin-ethylester

Z-Gly-Pro-Arg(NO)2-NH₂

Z-Gly-Pro-Arg(NO₂)-NHCH₃

Refernces