2-CHLORO-N,N-DIETHYLANILINE

Base Information

• Chemical Name: 2-CHLORO-N,N-DIETHYLANILINE
• CAS No.: 19372-80-6
• Molecular Formula: C10H14 Cl N
• Molecular Weight: 183.681
• Hs Code.: 2921420090
• Mol file: 19372-80-6.mol

Synonyms:Aniline,o-chloro-N,N-diethyl- (8CI)

Chemical Property of 2-CHLORO-N,N-DIETHYLANILINE

Chemical Property:

• Refractive Index: 1.5310-1.5330
• Boiling Point: 221 °C
• PKA: 5.97±0.38(Predicted)
• Flash Point: 98.4oC
• PSA: 3.24000
• Density: 1,05 g/cm3
• LogP: 3.18620
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Chloro-N,N-diethylaniline ^*data from reagent suppliers

Safty Information:

• Statements: 23/24/25-36/37/38
• Safety Statements: 36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-N,N-DIETHYLANILINE

There total 4 articles about 2-CHLORO-N,N-DIETHYLANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-(trimethylsilyl)phenyl trifluoromethanesulfonate (88284-48-4) + triethylamine (121-44-8) → 2-chloro-N,N-diethylaniline (19372-80-6)

Guidance literature:

With tetrachloromethane; potassium fluoride; 18-crown-6 ether; In tetrahydrofuran; at 65 ℃; for 10h; Sealed tube;

DOI:10.1039/c9cc05505c

Reference yield: 50.0%

ethanol (64-17-5) + 2-Chloronitrobenzene (88-73-3) → 2-chloro-N,N-diethylaniline (19372-80-6) + o-chloroaniline (95-51-2)

Guidance literature:

With Au NCs/TiO₂; for 4h; Reagent/catalyst; Kinetics; Inert atmosphere; UV-irradiation;

DOI:10.1039/c2cy20511d

Reference yield:

triethyl phosphate (78-40-0) + o-chloroaniline (95-51-2) → 2-chloro-N,N-diethylaniline (19372-80-6)

Guidance literature:

DOI:10.1021/ja01209a058

upstream raw materials:

triethyl phosphate

o-chloroaniline

ethanol

2-Chloronitrobenzene

Downstream raw materials:

(2-Chloro-4-nitro-phenyl)-ethyl-amine

Bis-3-diethylaminophenylamin

N,N-diethyl-1,3-benzenediamine

Refernces

• 1、 Stibal, David,Sa, Jacinto,Bokhoven, Jeroen A. Van. "One-pot photo-reductive N-alkylation of aniline and nitroarene derivatives with primary alcohols over Au-TiO2". . p. 94 - 98. Retrieved 2013/04/10.