2,3,5,6-tetrachloropyridine-4-carboxylic Acid

Base Information

• Chemical Name: 2,3,5,6-tetrachloropyridine-4-carboxylic Acid
• CAS No.: 19340-26-2
• Molecular Formula: C6H Cl4 N O2
• Molecular Weight: 260.891
• Hs Code.: 2933399090
• European Community (EC) Number: 659-464-3
• DSSTox Substance ID: DTXSID30402194
• Wikidata: Q82205569
• Mol file: 19340-26-2.mol

Synonyms:2,3,5,6-tetrachloropyridine-4-carboxylic Acid;19340-26-2;2,3,5,6-Tetrachloroisonicotinic acid;SCHEMBL7825411;DTXSID30402194;2,3,5,6-Tetrachloroisonicotinicacid;BBL103191;MFCD00092427;STL557001;AKOS024338472;MS-20572;CS-0163286;FT-0704771;TETRACHLOROPYRIDINE-4-CARBOXYLIC ACID;F20802;EN300-3080669;Z1269198921

Chemical Property of 2,3,5,6-tetrachloropyridine-4-carboxylic Acid

Chemical Property:

• Vapor Pressure: 4.85E-08mmHg at 25°C
• Melting Point: 220-222 °C
• Refractive Index: 1.629
• Boiling Point: 426.7°C at 760 mmHg
• PKA: -0.24±0.32(Predicted)
• Flash Point: 211.9°C
• PSA: 50.19000
• Density: 1.824g/cm³
• LogP: 3.39340
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 260.873189
• Heavy Atom Count: 13
• Complexity: 201

Purity/Quality:

99% ^*data from raw suppliers

2,3,5,6-TETRACHLORO-4-PYRIDINECARBOXYLIC ACID Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1(=C(C(=NC(=C1Cl)Cl)Cl)Cl)C(=O)O

Technology Process of 2,3,5,6-tetrachloropyridine-4-carboxylic Acid

There total 3 articles about 2,3,5,6-tetrachloropyridine-4-carboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

2,3,4,5,6-pentachloropyridine (2176-62-7) + carbon dioxide (124-38-9,18923-20-1) → tetrachloroisonicotic acid (19340-26-2)

Guidance literature:

2,3,4,5,6-pentachloropyridine; With n-butyllithium; In diethyl ether; hexane; at -55 ℃; for 0.5h; Inert atmosphere;

carbon dioxide; In diethyl ether; hexane; at -55 - 20 ℃; Inert atmosphere;

Reference yield:

4-carboxy-2,6-dihydroxypyridine (84660-84-4) → tetrachloroisonicotic acid (19340-26-2)

Guidance literature:

With phosphorus pentachloride; at 170 ℃; im Rohr; Behandeln mit Wasser oder mit methylalkoholischem Ammoniak und Verseifung mit Schwefelsaeure;

Reference yield:

→ tetrachloroisonicotic acid (19340-26-2)

Guidance literature:

Pentachlorpyridin (in Ae.), 1. BuLi, 2. CO2, 3. W.; (S.21);

DOI:10.1016/S0022-328X(00)88851-8

upstream raw materials:

4-carboxy-2,6-dihydroxypyridine

2,3,4,5,6-pentachloropyridine

carbon dioxide

Downstream raw materials:

2,3,5,6-tetrachloropyridine

2,6-diamino-3,5-dichloropyridine

2,3,4,5,6-pentachloropyridine

Refernces

• 1、 Moshchitskii et al.. "-". . . Retrieved 1970.