N-<2-<2-(diethylamino)ethoxy>ethyl>-N-methyl-1-phenyl-1-cyclopentanemethylamine

Base Information

• Chemical Name: N-<2-<2-(diethylamino)ethoxy>ethyl>-N-methyl-1-phenyl-1-cyclopentanemethylamine
• CAS No.: 136089-24-2
• Molecular Formula: C₂₁H₃₆N₂O
• Molecular Weight: 332.53
• Mol file: 136089-24-2.mol

Synonyms:N-<2-<2-(diethylamino)ethoxy>ethyl>-N-methyl-1-phenyl-1-cyclopentanemethylamine

Chemical Property of N-<2-<2-(diethylamino)ethoxy>ethyl>-N-methyl-1-phenyl-1-cyclopentanemethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<2-<2-(diethylamino)ethoxy>ethyl>-N-methyl-1-phenyl-1-cyclopentanemethylamine

There total 9 articles about N-<2-<2-(diethylamino)ethoxy>ethyl>-N-methyl-1-phenyl-1-cyclopentanemethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-phenylcyclopentanecarboxylic acid chloride (17380-62-0) → N-<2-<2-(diethylamino)ethoxy>ethyl>-N-methyl-1-phenyl-1-cyclopentanemethylamine (136089-24-2)

Guidance literature:

Multi-step reaction with 3 steps

1: NaHCO₃, pentane / CHCl₃; H₂O / 1 h / Ambient temperature

2: 74 percent / Red-Al / toluene / Heating

3: NaBH₃CN / acetonitrile; H₂O / 1 h / Ambient temperature

With sodium cyanoborohydride; sodium hydrogencarbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; pentane; In chloroform; water; toluene; acetonitrile;

DOI:10.1021/jm00115a002

Reference yield:

[2-(2-Azido-ethoxy)-ethyl]-diethyl-amine (136089-18-4) → N-<2-<2-(diethylamino)ethoxy>ethyl>-N-methyl-1-phenyl-1-cyclopentanemethylamine (136089-24-2)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂ / 10percent Pd/C / ethanol / 48 h / 2068.6 Torr / Ambient temperature

2: NaHCO₃, pentane / CHCl₃; H₂O / 1 h / Ambient temperature

3: 74 percent / Red-Al / toluene / Heating

4: NaBH₃CN / acetonitrile; H₂O / 1 h / Ambient temperature

With hydrogen; sodium cyanoborohydride; sodium hydrogencarbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; pentane; palladium on activated charcoal; In ethanol; chloroform; water; toluene; acetonitrile;

DOI:10.1021/jm00115a002

Reference yield:

2-[2-(diethylamino)ethoxy] ethanol (140-82-9) → N-<2-<2-(diethylamino)ethoxy>ethyl>-N-methyl-1-phenyl-1-cyclopentanemethylamine (136089-24-2)

Guidance literature:

Multi-step reaction with 5 steps

1: zinc-azide-bispyridine complex, triphenylphosphine, diisopropyl azodicarboxylate / toluene / 2 h / Ambient temperature

2: H₂ / 10percent Pd/C / ethanol / 48 h / 2068.6 Torr / Ambient temperature

3: NaHCO₃, pentane / CHCl₃; H₂O / 1 h / Ambient temperature

4: 74 percent / Red-Al / toluene / Heating

5: NaBH₃CN / acetonitrile; H₂O / 1 h / Ambient temperature

With Zn(N₃)2/bis-pyridine complex; di-isopropyl azodicarboxylate; hydrogen; sodium cyanoborohydride; sodium hydrogencarbonate; triphenylphosphine; sodium bis(2-methoxyethoxy)aluminium dihydride; pentane; palladium on activated charcoal; In ethanol; chloroform; water; toluene; acetonitrile;

DOI:10.1021/jm00115a002

upstream raw materials:

formaldehyd

N-<2-<2-(diethylamino)ethoxy>ethyl>-1-phenyl-1-cyclopentanemethylamine

1-phenyl-1-cyclopentanecarboxylic acid

2-<2-(diethylamino)ethoxy>ethylamine

Refernces