lisinopril diethyl ester

Base Information

• Chemical Name: lisinopril diethyl ester
• CAS No.: 877865-60-6
• Molecular Formula: C₂₅H₃₉N₃O₅
• Molecular Weight: 461.602
• Mol file: 877865-60-6.mol

Synonyms:lisinopril diethyl ester

Chemical Property of lisinopril diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of lisinopril diethyl ester

There total 1 articles about lisinopril diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanol (64-17-5) + Lisinopril (76547-98-3) → lisinopril diethyl ester (877865-60-6)

Guidance literature:

With thionyl chloride; for 3h; Reflux;

DOI:10.1016/j.bioorg.2013.06.007

Reference yield: 93.0%

lisinopril diethyl ester (877865-60-6) + 3-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-(1-(4-nitrophenoxy)-1,10-dioxo-2,9,14-trioxa-5,6-dithia-11-azapentadecan-15-yl)-1,4-dihydropyridine-3,5-dicarboxylate → 3-ethyl 5-methyl 4-(2-chlorophenyl)-2-((23S)-21-((R)-2-(ethoxycarbonyl)pyrrolidine-1-carbonyl)-6,15,24-trioxo-23-phenethyl-2,7,14,25-tetraoxa-10,11-dithia5,16,22-triazaheptacosyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:

In dichloromethane; at 0 ℃; for 0.333333h;

DOI:10.1016/j.bioorg.2013.06.007

Reference yield: 45.0%

3-ethyl 5-methyl 4-(2-chlorophenyl)-2-(13-hydroxy-6-oxo-2,7-dioxa-10,11-dithia-5-azatridecyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate + lisinopril diethyl ester (877865-60-6) → C51H70ClN5O14S2

Guidance literature:

3-ethyl 5-methyl 4-(2-chlorophenyl)-2-(13-hydroxy-6-oxo-2,7-dioxa-10,11-dithia-5-azatridecyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate; 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 20 ℃; for 3.5h;

lisinopril diethyl ester; In N,N-dimethyl-formamide; at 65 ℃; for 8h;

upstream raw materials:

ethanol

Lisinopril

Refernces

• 1、 -. "Prodrugs containing novel bio-cleavable linkers". Page/Page column 138. . Retrieved 2008/06/13.