(4-benzylpiperazin-1-yl)(cyclopropyl)methanone

Base Information

• Chemical Name: (4-benzylpiperazin-1-yl)(cyclopropyl)methanone
• CAS No.: 362474-71-3
• Molecular Formula: C₁₅H₂₀N₂O
• Molecular Weight: 244.337
• Mol file: 362474-71-3.mol

Synonyms:(4-benzylpiperazin-1-yl)(cyclopropyl)methanone

Chemical Property of (4-benzylpiperazin-1-yl)(cyclopropyl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-benzylpiperazin-1-yl)(cyclopropyl)methanone

There total 3 articles about (4-benzylpiperazin-1-yl)(cyclopropyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-phenylmethylpiperazine (2759-28-6) + cyclopropanecarboxylic acid chloride (4023-34-1) → (4-benzylpiperazin-1-yl)(cyclopropyl)methanone (362474-71-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 50 ℃; for 15h;

Reference yield: 70.0%

(4-benzylpiperazin-1-yl)(2,2-dibromocyclopropyl)methanone → (4-benzylpiperazin-1-yl)(cyclopropyl)methanone (362474-71-3)

Guidance literature:

With pyridine; sodium tetrahydroborate; 3,4,7,8-Tetramethyl-o-phenanthrolin; nickel(II) acetate tetrahydrate; In tetrahydrofuran; water; at 45 ℃; for 0.5h; under 760.051 Torr; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.202006162

Reference yield:

1-(1-oxo-2-propenyl)-4-(phenylmethyl)-piperazine (105875-99-8) → (4-benzylpiperazin-1-yl)(cyclopropyl)methanone (362474-71-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide

2: nickel(II) acetate tetrahydrate; sodium tetrahydroborate; 3,4,7,8-Tetramethyl-o-phenanthrolin; pyridine / water; tetrahydrofuran / 0.5 h / 45 °C / 760.05 Torr / Inert atmosphere; Sealed tube

With pyridine; sodium tetrahydroborate; 3,4,7,8-Tetramethyl-o-phenanthrolin; nickel(II) acetate tetrahydrate; sodium hydroxide; In tetrahydrofuran; water;

DOI:10.1002/anie.202006162

upstream raw materials:

1-phenylmethylpiperazine

cyclopropanecarboxylic acid chloride

1-(1-oxo-2-propenyl)-4-(phenylmethyl)-piperazine

Downstream raw materials:

1-(cyclopropylcarbonyl)piperazine

Refernces

• 1、 -. "PYRROLO[2,1-F] [1,2,4] TRIAZIN-4-YLAMINES IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES". Page/Page column 102. . Retrieved 2010/11/27.