3-(3-bromophenyl)-N-cyclopropylpropanamide

Base Information

• Chemical Name: 3-(3-bromophenyl)-N-cyclopropylpropanamide
• CAS No.: 1378311-80-8
• Molecular Formula: C₁₂H₁₄BrNO
• Molecular Weight: 268.153
• Mol file: 1378311-80-8.mol

Synonyms:3-(3-bromophenyl)-N-cyclopropylpropanamide

Chemical Property of 3-(3-bromophenyl)-N-cyclopropylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 3-(3-bromophenyl)-N-cyclopropylpropanamide

There total 3 articles about 3-(3-bromophenyl)-N-cyclopropylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

Cyclopropylamine (765-30-0) + 3-(m-bromophenyl)propionyl chloride (335159-82-5) → 3-(3-bromophenyl)-N-cyclopropylpropanamide (1378311-80-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield: 79.0%

3-(3-bromophenyl)propanoic acid (42287-90-1) + Cyclopropylamine (765-30-0) → 3-(3-bromophenyl)-N-cyclopropylpropanamide (1378311-80-8)

Guidance literature:

3-(3-bromophenyl)propanoic acid; With thionyl chloride; at 70 ℃; for 2h;

Cyclopropylamine; With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

3-(3-bromophenyl)propanoic acid (42287-90-1) → 3-(3-bromophenyl)-N-cyclopropylpropanamide (1378311-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 2 h / 70 °C

2: triethylamine / dichloromethane / 0 - 20 °C

With thionyl chloride; triethylamine; In dichloromethane;

upstream raw materials:

3-(3-bromophenyl)propanoic acid

Cyclopropylamine

3-(m-bromophenyl)propionyl chloride

Downstream raw materials:

tert-butyl 5-(tert-butoxycarbonyl(2-(3-(3-(cyclopropylamino)-3-oxopropyl)phenyl)pyrimidin-4-yl)amino)-1H-indazole-1-carboxylate

3-(3-(4-(1H-indazol-5-ylamino)pyrimidin-2-yl)phenyl)-N-cyclopropylpropanamide

N-cyclopropyl-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanamide

Refernces

• 1、 -. "TREATMENT OF OCULAR DISORDERS". . . Retrieved 2014/04/18.