(Z)-3-(Dimethylamino)-2-methylacrylaldehyde

Base Information

• Chemical Name: (Z)-3-(Dimethylamino)-2-methylacrylaldehyde
• CAS No.: 19125-76-9
• Molecular Formula: C6H11NO
• Molecular Weight: 113.159
• Hs Code.: 2922399090
• European Community (EC) Number: 626-683-0
• UNII: 2ER2JC4ZV2
• Mol file: 19125-76-9.mol

Synonyms:(Z)-3-(Dimethylamino)-2-methylacrylaldehyde;85907-39-7;(Z)-3-(dimethylamino)-2-methylprop-2-enal;(2Z)-3-(dimethylamino)-2-methylacrylaldehyde;19125-76-9;2ER2JC4ZV2;SCHEMBL12547389;AKOS015959940;(2E)-3-(dimethylamino)-2-methylacrylaldehyde;F13117;3-(Dimethylamino)-2-methyl-2-propenal, (2Z)-;2-Propenal, 3-(dimethylamino)-2-methyl-, (Z)-

Chemical Property of (Z)-3-(Dimethylamino)-2-methylacrylaldehyde

Chemical Property:

• Vapor Pressure: 0.00119mmHg at 25°C
• Melting Point: 34-38 °C
• Refractive Index: 1.448
• Boiling Point: 299.5 °C at 760 mmHg
• Flash Point: 124.6 °C
• PSA: 20.31000
• Density: 0.901 g/cm³
• LogP: 0.65070
• Storage Temp.: 2-8°C
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 113.084063974
• Heavy Atom Count: 8
• Complexity: 105

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-(Dimethylamino)-2-methylacrylaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=CN(C)C)C=O
• Isomeric SMILES: C/C(=C/N(C)C)/C=O
• Uses: 3-(Dimethylamino)-2-methyl-2-propenal is suitable for use in the synthesis of methylmalondialdehyde.

Technology Process of (Z)-3-(Dimethylamino)-2-methylacrylaldehyde

There total 5 articles about (Z)-3-(Dimethylamino)-2-methylacrylaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-diethoxypropane (4744-08-5) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-dimethylamino-2-methyl-acrylaldehyde (19125-76-9) + 3-ethoxymethacrolein (42588-57-8)

Guidance literature:

With trichlorophosphate; Yield given. Multistep reaction. Yields of byproduct given; 1.) <30 deg C, 2.) 70 deg C, 2 h;

DOI:10.1021/ja00401a020

Reference yield:

ethyl 1-propenyl ether (928-55-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-dimethylamino-2-methyl-acrylaldehyde (19125-76-9)

Guidance literature:

With potassium carbonate; trichlorophosphate; Yield given. Multistep reaction; 1.) 1,2-dichloroethane, room temperature, 15 min, then 0 deg C and 70 deg C, 40 min, 2.) 0 deg C;

DOI:10.1016/S0040-4020(01)89943-9

Reference yield:

phosgene (75-44-5) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-dimethylamino-2-methyl-acrylaldehyde (19125-76-9)

Guidance literature:

With 1,2-dichloro-ethane; und Behandeln des Reaktionsgemisches mit Propionaldehyd-diaethylacetal;

upstream raw materials:

phosgene

N,N-dimethyl-formamide

1,1-diethoxypropane

ethyl 1-propenyl ether

Downstream raw materials:

2-methyl-1,3-propanedialdehyde

2,6-diethyl-4-methylphenol

ethyl 5-methyl-2-oxo-1-(4-fluorophenyl)-1,2-dihydropyridine-3-carboxylate

N,N,N’,N’-3-pentamethyl-1,5-diazapenta-1,3-dienium picrate

Refernces