N1-(2,6-DIFLUOROPHENYL)-2-CHLOROACETAMIDE

Base Information

• Chemical Name: N1-(2,6-DIFLUOROPHENYL)-2-CHLOROACETAMIDE
• CAS No.: 19064-26-7
• Molecular Formula: C8H6 Cl F2 N O
• Molecular Weight: 205.592
• Hs Code.: 2924299090
• Mol file: 19064-26-7.mol

Synonyms:Acetanilide,2-chloro-2',6'-difluoro- (8CI)

Chemical Property of N1-(2,6-DIFLUOROPHENYL)-2-CHLOROACETAMIDE

Chemical Property:

• Vapor Pressure: 0.000983mmHg at 25°C
• Refractive Index: 1.55
• Boiling Point: 302.5°C at 760 mmHg
• Flash Point: 136.8°C
• PSA: 29.10000
• Density: 1.444g/cm³
• LogP: 2.21510

Purity/Quality:

98% ^*data from raw suppliers

N1-(2,6-Difluorophenyl)-2-chloroacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N1-(2,6-DIFLUOROPHENYL)-2-CHLOROACETAMIDE

There total 1 articles about N1-(2,6-DIFLUOROPHENYL)-2-CHLOROACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-difluoroaniline (5509-65-9) + chloroacetyl chloride (79-04-9) → N-(2,6-Difluor-phenyl)-chloracetamid (19064-26-7)

Guidance literature:

With sodium hydroxide; In diethyl ether; water; at 20 ℃; for 0.833333h;

Reference yield: 88.4%

5-((4,6-dimethylpyrimidin-2-yl)thiomethyl)-1,3,4-thiadiazole-2-thiol + N-(2,6-Difluor-phenyl)-chloracetamid (19064-26-7) → C17H15F2N5OS3

Guidance literature:

With sodium hydroxide; In ethanol; water;

Reference yield: 77.0%

morpholine (110-91-8,99108-56-2) + N-(2,6-Difluor-phenyl)-chloracetamid (19064-26-7) → C12H12F2N2O2S (1017590-13-4)

Guidance literature:

With sulfur; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

2,6-difluoroaniline

chloroacetyl chloride

Downstream raw materials:

C₁₂H₁₂F₂N₂O₂S

N-(2,6-difluorophenyl)-2-(4-(4-(pyridin-4-ylmethyl)phthalazin-1-yl)piperazin-1-yl)acetamide

N-(2,6-difluorophenyl)-2-(4-(4-benzylphthalazin-1-yl)piperazin-1-yl)acetamide

Refernces

• 1、 Zhang, Yilin,Yan, Yong,Liang, Lufan,Jiefeng,Wang, Xuejun,Li, Li,Yang, Kewu. "Halogen-substituted triazolethioacetamides as a potent skeleton for the development of metallo-β-lactamase inhibitors". . . Retrieved 2019/04/03.
• 2、 -. "FUSED RING COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES". Page/Page column 148. . Retrieved 2008/06/13.