(4-benzyloxycarbonylamino-4-methyl piperidin-1-yl)-oxo-acetic acid

Base Information

• Chemical Name: (4-benzyloxycarbonylamino-4-methyl piperidin-1-yl)-oxo-acetic acid
• CAS No.: 1187321-73-8
• Molecular Formula: C₁₆H₂₀N₂O₅
• Molecular Weight: 320.345
• Mol file: 1187321-73-8.mol

Synonyms:(4-benzyloxycarbonylamino-4-methyl piperidin-1-yl)-oxo-acetic acid

Chemical Property of (4-benzyloxycarbonylamino-4-methyl piperidin-1-yl)-oxo-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (4-benzyloxycarbonylamino-4-methyl piperidin-1-yl)-oxo-acetic acid

There total 2 articles about (4-benzyloxycarbonylamino-4-methyl piperidin-1-yl)-oxo-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-benzyloxycarbonylamino-4-methylpiperidin-1-yl)-oxo-acetic acid ethyl ester (1187321-72-7) → (4-benzyloxycarbonylamino-4-methyl piperidin-1-yl)-oxo-acetic acid (1187321-73-8)

Guidance literature:

With water; sodium hydroxide; In ethanol; at 20 ℃; for 0.5h;

Reference yield:

(4-methyl-piperidin-4-yl)-carbamic acid benzyl ester (236406-15-8) → (4-benzyloxycarbonylamino-4-methyl piperidin-1-yl)-oxo-acetic acid (1187321-73-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dmap / acetonitrile / 0 - 20 °C

2: water; sodium hydroxide / ethanol / 0.5 h / 20 °C

With water; triethylamine; sodium hydroxide; dmap; In ethanol; acetonitrile;

Reference yield:

(4-benzyloxycarbonylamino-4-methyl piperidin-1-yl)-oxo-acetic acid (1187321-73-8) + 5-amino-5-deoxy-1,2-O-isopropylidene-a-D-xylofuranose (4613-58-5,25531-86-6,25572-88-7) → C24H33N3O8 (1187322-20-8)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 20 ℃; for 1h;

upstream raw materials:

(4-benzyloxycarbonylamino-4-methylpiperidin-1-yl)-oxo-acetic acid ethyl ester

(4-methyl-piperidin-4-yl)-carbamic acid benzyl ester

Downstream raw materials:

C₂₄H₃₃N₃O₈

C₂₈H₃₉N₃O₉

C₂₅H₃₅N₃O₈

2-(4-amino-4-methylpiperidin-1-yl)-N-(6,7-dihydroxy-2,2-dimethyltetrahydro-[1,3]-dioxolo[4,5-b]pyran-3a-ylmethyl)-2-oxo-acetamide

Refernces