C₁₆H₁₈ClNO₄S

Base Information

• Chemical Name: C₁₆H₁₈ClNO₄S
• CAS No.: 1351983-68-0
• Molecular Formula: C₁₆H₁₈ClNO₄S
• Molecular Weight: 355.842
• Mol file: 1351983-68-0.mol

Synonyms:C₁₆H₁₈ClNO₄S

Chemical Property of C₁₆H₁₈ClNO₄S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of C₁₆H₁₈ClNO₄S

There total 2 articles about C₁₆H₁₈ClNO₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Oxoclopidogrel (1147350-75-1,109904-27-0) → R-361015 (767612-34-0) + C16H18ClNO4S (1351983-68-0)

Guidance literature:

With potassium fluoride; NADPH; ascorbic acid; at 37 ℃; for 0.5h; pH=7.4; aq. phosphate buffer; Microbiological reaction;

DOI:10.1021/tx2004085

Reference yield:

(S)-(+)-clopidogrel (113665-84-2,94188-84-8) → C16H18ClNO4S (1351983-68-0)

Guidance literature:

Multi-step reaction with 2 steps

1: cytochrome P₄₅₀ / Enzymatic reaction

2: paraoxonase-1 / Enzymatic reaction

With paraoxonase-1; cytochrome P₄₅₀;

DOI:10.1021/acs.chemrestox.5b00133

Reference yield: 65.8%

C16H18ClNO4S (1351983-68-0) → bis-methyl-(S)-2-(1-(1-(2-chlorophenyl)-2-carboxyethyl)-4-mercapto-1,2,5,6-tetrahydropyridin-3-yl)acetate

Guidance literature:

With bis(trichloromethyl) carbonate; triethylamine; triphenylphosphine; In chloroform; at 0 - 65 ℃; Inert atmosphere;

upstream raw materials:

2-Oxoclopidogrel

(S)-(+)-clopidogrel

Refernces

• 1、 Dansette, Patrick M.,Rosi, Julien,Bertho, Gildas,Mansuy, Daniel. "Cytochromes P450 catalyze both steps of the major pathway of clopidogrel bioactivation, whereas paraoxonase catalyzes the formation of a minor thiol metabolite isomer". experimental part. p. 348 - 356. Retrieved 2012/06/30.