2-BROMO-6-FLUORO-4-METHYLANILINE

Base Information

• Chemical Name: 2-BROMO-6-FLUORO-4-METHYLANILINE
• CAS No.: 18349-09-2
• Molecular Formula: C7H7 Br F N
• Molecular Weight: 204.042
• Hs Code.: 2921430090
• Mol file: 18349-09-2.mol

Synonyms:p-Toluidine,2-bromo-6-fluoro- (8CI); 2-Bromo-6-fluoro-4-methylaniline

Chemical Property of 2-BROMO-6-FLUORO-4-METHYLANILINE

Chemical Property:

• Vapor Pressure: 0.0617mmHg at 25°C
• Refractive Index: 1.584
• Boiling Point: 231.6°C at 760 mmHg
• Flash Point: 93.9°C
• PSA: 26.02000
• Density: 1.589g/cm³
• LogP: 3.06000
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%Min ^*data from raw suppliers

2-Bromo-6-fluoro-4-methylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-6-FLUORO-4-METHYLANILINE

There total 1 articles about 2-BROMO-6-FLUORO-4-METHYLANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-fluoro-4-methylaniline (452-80-2) → 2-bromo-6-fluoro-4-methyl aniline (18349-09-2)

Guidance literature:

With N-Bromosuccinimide; In acetic acid; at 15 - 20 ℃; for 1.66667h;

Reference yield: 93.0%

2-bromo-6-fluoro-4-methyl aniline (18349-09-2) + trifluoroacetic anhydride (407-25-0) → N-(2-bromo-6-fluoro-4-methylphenyl)-2,2,2-trifluoroacetamide

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 90.0%

2-bromo-6-fluoro-4-methyl aniline (18349-09-2) + 2-methyl-but-3-yn-2-ol (115-19-5) → C12H14FNO (1403878-71-6)

Guidance literature:

With palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether; In 1-methyl-pyrrolidin-2-one; at 22 ℃;

DOI:10.1021/op300249q

upstream raw materials:

2-fluoro-4-methylaniline

Downstream raw materials:

2-bromo-6-fluoro-4-methylbenzonitrile

7-fluoro-5-methyl-1H-indole

1,1-dimethylethyl4-({[(2-bromo-6-fluoro-4-methylphenyl)-amino]carbonyl}amino)-1-piperidinecarboxylate

2-bromo-6-fluoro-4-methylbenzaldehyde

Refernces

• 1、 Cooze, Christopher,Dada, Raphael,Lundgren, Rylan J.. "Direct Formic Acid Mediated Z-Selective Reductive Coupling of Dienes and Aldehydes". supporting information. p. 12246 - 12251. Retrieved 2019/08/01.
• 2、 -. "CARBOXY SUBSTITUTED (HETERO) AROMATIC RING DERIVATIVES AND PREPARATION METHOD AND USES THEREOF". Page/Page column 123; 124. . Retrieved 2017/03/21.