Uracil, dimer, syn- (8CI)

Base Information

• Chemical Name: Uracil, dimer, syn- (8CI)
• CAS No.: 18324-22-6
• Molecular Formula: C₄H₄N₂O₂
• Molecular Weight: 112.088
• Mol file: 18324-22-6.mol

Synonyms:Uracil, dimer, syn- (8CI)

Chemical Property of Uracil, dimer, syn- (8CI)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Uracil, dimer, syn- (8CI)

There total 286 articles about Uracil, dimer, syn- (8CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

1,2,4-triazole-3-carboxamide (3641-08-5) + uridine (58-96-8) → uracil (66-22-8,144104-68-7,18324-22-6,27072-01-1,2920-92-5,51953-19-6) + ribavirin (36791-04-5,66510-90-5)

Guidance literature:

With aeromonas hydrophila CECT 4226; at 60 ℃; for 26h; pH=7; aq. phosphate buffer; Enzymatic reaction;

DOI:10.3109/10242422.2010.538949

Reference yield: 58.0%

hypoxanthine (68-94-0) + 2',3'-Dideoxyuridine (5983-09-5,153547-98-9) → Dideoxyinosine (69655-05-6) + uracil (66-22-8,144104-68-7,18324-22-6,27072-01-1,2920-92-5,51953-19-6)

Guidance literature:

With aeromonas hydrophila CECT 4221; at 45 ℃; for 16h; pH=7; aq. phosphate buffer; Enzymatic reaction;

DOI:10.3109/10242422.2010.538949

Reference yield:

2,6 dichloropurine (5451-40-1) + uridine (58-96-8) → uracil (66-22-8,144104-68-7,18324-22-6,27072-01-1,2920-92-5,51953-19-6) + 2,6-dichloropurine riboside (13276-52-3)

Guidance literature:

With potassium phosphate; at 40 ℃; for 6h; pH=7.5; Equilibrium constant; Enzymatic reaction;

DOI:10.3390/molecules25040934

upstream raw materials:

pyridine

5-bromo-dihydro-pyrimidine-2,4-dione

2-thiouracil

5,6-dhydrouracil

Downstream raw materials:

3-Morpholinomethyl-uracil

N-(2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylmethyl)-phthalimide

1-acetyl-1H-pyrimidine-2,4-dione

uracilacetic acid

Refernces

• 1、 Kaspar, Felix,Neubauer, Peter,Kurreck, Anke. "The Peculiar Case of the Hyper-thermostable Pyrimidine Nucleoside Phosphorylase from Thermus thermophilus**". . p. 1385 - 1390. Retrieved 2021/01/29.
• 2、 Giessmann, Robert T.,Kaspar, Felix,Klare, Hendrik F. T.,Kurreck, Jens,Neubauer, Peter,Paulick, Katharina,R?hrs, Viola,Wagner, Anke,Westarp, Sarah,Yehia, Heba. "Efficient biocatalytic synthesis of dihalogenated purine nucleoside analogues applying thermodynamic calculations". . . Retrieved 2020/02/28.