BZ-D-ALA-OH

Base Information

• Chemical Name: BZ-D-ALA-OH
• CAS No.: 17966-60-8
• Molecular Formula: C10H11 N O3
• Molecular Weight: 193.202
• Hs Code.: 2924299090
• Mol file: 17966-60-8.mol

Synonyms:Alanine,N-benzoyl-, D- (8CI); (R)-2-(Benzoylamino)propanoic acid; Benzoyl-D-alanine;D-N-Benzoylalanine; N-Benzoyl-D-alanine

Chemical Property of BZ-D-ALA-OH

Chemical Property:

• Vapor Pressure: 5.7E-09mmHg at 25°C
• Melting Point: 147-148℃
• Refractive Index: 1.555
• Boiling Point: 452.3°C at 760 mmHg
• Flash Point: 227.4°C
• PSA: 66.40000
• Density: 1.224
• LogP: 1.28040
• Storage Temp.: Store at RT.

Purity/Quality:

98%,99%, ^*data from raw suppliers

Benzoyl-D-alanine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BZ-D-ALA-OH

There total 20 articles about BZ-D-ALA-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

D-Alanine (338-69-2,25191-17-7,18875-37-1) + benzoyl chloride (98-88-4) → D-N-benzoylalanine (17966-60-8,90988-29-7)

Guidance literature:

In water; at 0 ℃; pH=10;

DOI:10.3998/ark.5550190.p009.621

Reference yield: 72.0%

(1R,2S,5R)-8-Phenylmenthyl N-benzoyl-(R)-alaninate (161755-13-1) → D-N-benzoylalanine (17966-60-8,90988-29-7)

Guidance literature:

With 18-crown-6 ether; In benzene; at 50 ℃; for 96h;

DOI:10.1021/jo00110a029

Reference yield: 51.0%

C13H11F6NO3 → D-N-benzoylalanine (17966-60-8,90988-29-7) + N-benzoyl-L-alanine (2198-64-3,90988-29-7)

Guidance literature:

With C₂₈H₃₀N₃O₂⁽¹⁺⁾*Br^(1-); sodium hydroxide; In chloroform; at 0 ℃; for 24h;

DOI:10.1021/acscatal.8b00693

upstream raw materials:

N-Benzoylalanine

strychnidin-10-one

2-phenyl-4-methyl-4H-oxazolin-5-one

methyl N-benzoylalaninate

Downstream raw materials:

(R)-2-(2-benzamidopropanoylthio)acetic acid

(S)-2-(2-benzamidopropanoylthio)acetic acid

(R)-2-((R)-2-Benzoylamino-propionylamino)-propionic acid

N-benzoyl-L-alanine

Refernces

• 1、 Simon, Justine F.,Bouillez, André,Frère, Jean-Marie,Luxen, André,Zervosen, Astrid. "Synthesis of an enantiopure thioester as key substrate for screening the sensitivity of penicillin binding proteins to inhibitors". . p. 22 - 31. Retrieved 2016/10/31.
• 2、 Kong, Hyesik,Kim, Hyunjeong,Do, Heejeong,Lee, Yonghyun,Hong, Sungchae,Yoon, Jeong-Hyun,Jung, Yunjin,Kim, Young Mi. "Structural effects of N-aromatic acyl-amino acid conjugates on their deconjugation in the cecal contents of rats: Implication in design of a colon-specific prodrug with controlled conversion rate at the target site". experimental part. p. 343 - 354. Retrieved 2012/04/10.