2-METHYL HYDROGEN PYRIDINE-2,5-DICARBOXYLATE

Base Information

• Chemical Name: 2-METHYL HYDROGEN PYRIDINE-2,5-DICARBOXYLATE
• CAS No.: 17874-76-9
• Molecular Formula: C8H7 N O4
• Molecular Weight: 181.148
• Hs Code.: 2933399090
• Mol file: 17874-76-9.mol

Synonyms:2-(Methoxycarbonyl)-5-pyridinecarboxylicacid; 3-Carboxy-6-methoxycarbonylpyridine; 5-Carboxy-2-(methoxycarbonyl)pyridine;6-(Methoxycarbonyl)nicotinic acid; 6-Carbomethoxynicotinic acid;6-Methoxycarbonyl-3-pyridinecarboxylic acid

Chemical Property of 2-METHYL HYDROGEN PYRIDINE-2,5-DICARBOXYLATE

Chemical Property:

• Vapor Pressure: 1.41E-06mmHg at 25°C
• Refractive Index: 1.56
• Boiling Point: 383.8ºC at 760 mmHg
• Flash Point: 185.9ºC
• PSA: 76.49000
• Density: 1.361g/cm3
• LogP: 0.56640
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-(Methoxycarbonyl)nicotinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHYL HYDROGEN PYRIDINE-2,5-DICARBOXYLATE

There total 6 articles about 2-METHYL HYDROGEN PYRIDINE-2,5-DICARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

methanol (67-56-1) + Pyridine-2,5-dicarboxylic acid (100-26-5) → 6-(methoxycarbonyl)nicotinic acid (17874-76-9)

Guidance literature:

With sulfuric acid; In water; at 0.7 ℃;

DOI:10.1039/c9dt00739c

Reference yield:

Pyridine-2,5-dicarboxylic acid (100-26-5) → 6-(methoxycarbonyl)nicotinic acid (17874-76-9)

Guidance literature:

With hydrogenchloride; sulfuric acid; In methanol; sodium hydroxide; water;

Reference yield:

Pyridine-2,5-dicarboxylic acid (100-26-5) + sulfuric acid (7664-93-9) → 6-(methoxycarbonyl)nicotinic acid (17874-76-9)

Guidance literature:

In methanol;

upstream raw materials:

methanol

Pyridine-2,5-dicarboxylic acid

sulfuric acid

S-adenosyl-L-methionine

Downstream raw materials:

5-hydroxymethyl-pyridine-2-carboxylic acid methyl ester

(S)-5-(((4-(trifluoromethyl)phenyl)(3-(trifluoromethyl)-pyridin-2-yl)methyl)carbamoyl)picolinic acid 2,2,2-trifluoroacetate

5-(1-(7-(3,4-dimethoxyphenylamino)thiazolo[5,4-d]pyrimidin-5-yl)pyrrolidin-3-ylcarbamoyl)picolinic acid

methyl 5-(1-(7-(3,4-dimethoxyphenylamino)thiazolo[5,4-d]pyrimidin-5-yl)pyrrolidin-3-ylcarbamoyl)picolinate

Refernces

• 1、 Ooi,Magee. "-". . p. 3315. Retrieved 1970.
• 2、 Ashbrook, Chloe,Carnell, Andrew J.,Goulding, Ellie,Hatton, Harry,Johnson, James R.,Kershaw, Neil M.,McCue, Hannah V.,Rigden, Daniel J.,Ward, Lucy C.. "Carboxyl Methyltransferase Catalysed Formation of Mono- and Dimethyl Esters under Aqueous Conditions: Application in Cascade Biocatalysis". supporting information. . Retrieved 2022/02/21.
• 3、 -. "COMPOUNDS AND METHODS FOR CONJUGATION OF BIOMOLECULES". Page/Page column 89. . Retrieved 2012/09/22.