[2-(α-(dimethylamino)ethyl)-1,1'-ferrocenediyl]phenylphosphine

Base Information

• Chemical Name: [2-(α-(dimethylamino)ethyl)-1,1'-ferrocenediyl]phenylphosphine
• CAS No.: 83560-65-0
• Molecular Formula: C₂₀H₂₂FeNP
• Molecular Weight: 363.222
• Mol file: 83560-65-0.mol

Synonyms:[2-(α-(dimethylamino)ethyl)-1,1'-ferrocenediyl]phenylphosphine

Chemical Property of [2-(α-(dimethylamino)ethyl)-1,1'-ferrocenediyl]phenylphosphine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [2-(α-(dimethylamino)ethyl)-1,1'-ferrocenediyl]phenylphosphine

There total 1 articles about [2-(α-(dimethylamino)ethyl)-1,1'-ferrocenediyl]phenylphosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1'-dilithio-2-α-Me-α-(dimethylamino)methylferrocene-tetramethylethylenediamine (83547-84-6) + Dichlorophenylphosphine (644-97-3) → [2-(α-(dimethylamino)ethyl)-1,1'-ferrocenediyl]phenylphosphine (83560-65-0)

Guidance literature:

In diethyl ether; (N2); Cl2PC6H5/Et2O added to stirred complex suspn. at -78°C, allowed to warm to room temp., stirred for 1 h; hydrolyzed with H2O, ethereal layer sepd., dried (MgSO4), concd., chromd. (Al2O3, Et2O), concd., hexane added, cooled to -20°C overnight; elem. anal.;

DOI:10.1021/om00073a024

Reference yield: 55.0%

[2-(α-(dimethylamino)ethyl)-1,1'-ferrocenediyl]phenylphosphine (83560-65-0) + phenyllithium (591-51-5) → N,N-dimethyl-(2-(diphenylphosphino)ferrocenyl)-1-(methyl-1-methylamine) (55700-44-2,60816-98-0,137695-36-4,105088-01-5,74311-54-9,55650-58-3) + (.eta5-(C6H5)2PC5H4)Fe(η5-(CH3C(H)NMe2)C5H4) (85150-25-0,103948-69-2)

Guidance literature:

With water; In diethyl ether; under N2 atm. to etheral soln. phenyllithium at -78°C soln. (Me2NC(CH3)HC5H3)Fe(C5H4)P(C6H5) in ether added dropwise and stirred for 5 min at -78°C before it warmed slowly to room temp., water added; etheral layer separated, dried over anhyd. MgSO4, volume reduced, residue redissolved in chloroform and chromed. with hexane/ether 50/50 as eluent, then with Et2O, solvent removed, product recrystd. at -20°C from hexane; elem. anal.;

upstream raw materials:

1,1'-dilithio-2-α-Me-α-(dimethylamino)methylferrocene-tetramethylethylenediamine

Dichlorophenylphosphine

Downstream raw materials:

N,N-dimethyl-(2-(diphenylphosphino)ferrocenyl)-1-(methyl-1-methylamine)

(.eta5-(C6H5)2PC5H4)Fe(η5-(CH3C(H)NMe2)C5H4)

Refernces