(R,R_S)-N-[1-(3,4-dibenzyloxyphenyl)propan-2-yl]tertbutylsulfinamide

Base Information

• Chemical Name: (R,R_S)-N-[1-(3,4-dibenzyloxyphenyl)propan-2-yl]tertbutylsulfinamide
• CAS No.: 1616296-98-0
• Molecular Formula: C₂₇H₃₃NO₃S
• Molecular Weight: 451.63
• Mol file: 1616296-98-0.mol

Synonyms:(R,R_S)-N-[1-(3,4-dibenzyloxyphenyl)propan-2-yl]tertbutylsulfinamide

Chemical Property of (R,R_S)-N-[1-(3,4-dibenzyloxyphenyl)propan-2-yl]tertbutylsulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,R_S)-N-[1-(3,4-dibenzyloxyphenyl)propan-2-yl]tertbutylsulfinamide

There total 4 articles about (R,R_S)-N-[1-(3,4-dibenzyloxyphenyl)propan-2-yl]tertbutylsulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C27H31NO3S → (R,RS)-N-[1-(3,4-dibenzyloxyphenyl)propan-2-yl]tertbutylsulfinamide (1616296-98-0) + (S,RS)-N-[1-(3,4-dibenzyloxyphenyl)propan-2-yl]tertbutylsulfinamide (1616297-05-2)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; at -20 - 20 ℃; for 3h;

DOI:10.1016/j.ejmech.2014.04.044

Reference yield:

3,4-dibenzyloxybenzaldehyde (5447-02-9) → (R,RS)-N-[1-(3,4-dibenzyloxyphenyl)propan-2-yl]tertbutylsulfinamide (1616296-98-0) + (S,RS)-N-[1-(3,4-dibenzyloxyphenyl)propan-2-yl]tertbutylsulfinamide (1616297-05-2)

Guidance literature:

Multi-step reaction with 4 steps

1: ammonium acetate / 17 h / Reflux

2: iron; iron(III) chloride; hydrogenchloride / water; ethanol / 5 h / Reflux

3: titanium(IV) tetraethanolate / tetrahydrofuran / 5 h / Reflux

4: sodium tetrahydroborate / tetrahydrofuran / 3 h / -20 - 20 °C

With hydrogenchloride; iron(III) chloride; titanium(IV) tetraethanolate; sodium tetrahydroborate; ammonium acetate; iron; In tetrahydrofuran; ethanol; water;

DOI:10.1016/j.ejmech.2014.04.044

Reference yield:

(E)-1,2-dibenzyloxy-4-(2-nitroprop-1-en-1-yl)benzene (62932-96-1) → (R,RS)-N-[1-(3,4-dibenzyloxyphenyl)propan-2-yl]tertbutylsulfinamide (1616296-98-0) + (S,RS)-N-[1-(3,4-dibenzyloxyphenyl)propan-2-yl]tertbutylsulfinamide (1616297-05-2)

Guidance literature:

Multi-step reaction with 3 steps

1: iron; iron(III) chloride; hydrogenchloride / water; ethanol / 5 h / Reflux

2: titanium(IV) tetraethanolate / tetrahydrofuran / 5 h / Reflux

3: sodium tetrahydroborate / tetrahydrofuran / 3 h / -20 - 20 °C

With hydrogenchloride; iron(III) chloride; titanium(IV) tetraethanolate; sodium tetrahydroborate; iron; In tetrahydrofuran; ethanol; water;

DOI:10.1016/j.ejmech.2014.04.044

upstream raw materials:

3,4-dibenzyloxybenzaldehyde

(E)-1,2-dibenzyloxy-4-(2-nitroprop-1-en-1-yl)benzene

1-(3,4-bis(benzyloxy)phenyl)propan-2-one

Downstream raw materials:

(R)-ethyl [1-(3,4-dihydroxyphenyl)propan-2-yl]carbamate

(-)-3,4-Methylenedioxymethamphetamine

(R)-ethyl [1-(3,4-dibenzyloxyphenyl)propan-2-yl]carbamate

(R,R_S)-N-[1-(3,4-dibenzyloxyphenyl)propan-2-yl]-N-methyltert-butylsulfinamide

Refernces