2,3,4,5-Tetrachloro-6-fluoropyridine

Base Information

• Chemical Name: 2,3,4,5-Tetrachloro-6-fluoropyridine
• CAS No.: 17717-16-7
• Molecular Formula: C5Cl4 F N
• Molecular Weight: 234.872
• Hs Code.: 2933399090
• Mol file: 17717-16-7.mol

Synonyms:2,3,4,5-Tetrachloro-6-fluoropyridine;2-Fluorotetrachloropyridine; Tetrachloro-2-fluoropyridine

Chemical Property of 2,3,4,5-Tetrachloro-6-fluoropyridine

Chemical Property:

• PSA: 12.89000
• LogP: 3.83430

Purity/Quality:

97% ^*data from raw suppliers

2,3,4,5-TETRACHLORO-6-FLUOROPYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3,4,5-Tetrachloro-6-fluoropyridine

There total 9 articles about 2,3,4,5-Tetrachloro-6-fluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

tetrachloromethane (56-23-5) + 2-fluoropyridine (372-48-5) → tetrachloro-monofluoropyridine (17717-16-7)

Guidance literature:

In gas; Evaporation of FC5H4N and solvent CCl4 between 300 and 350 °C, chlorination at 695 °C (dwell time 17.3 s).;

Reference yield: 27.0%

potassium fluoride (7789-23-3) + 2,3,4,5,6-pentachloropyridine (2176-62-7) → 2,4,6-trichloro-3,5-difluoropyridine (52074-51-8) + 2,6-difluoro-3,4,5-trichloropyridine (5958-25-8) + tetrachloro-monofluoropyridine (17717-16-7)

Guidance literature:

In sulfolane; Fluorination at 150 °C (4.5 h).;

Reference yield:

2,3,4,5,6-pentachloropyridine (2176-62-7) → 2,6-difluoro-3,4,5-trichloropyridine (5958-25-8) + tetrachloro-monofluoropyridine (17717-16-7) + 3,5-dichloro-2,4,6-trifluoropyridine (1737-93-5,259875-95-1)

Guidance literature:

With hydrogen fluoride; In isopropyl alcohol; at 0 - 140 ℃; Flow reactor; Green chemistry;

upstream raw materials:

Pentafluoropyridine

2,3,4,5,6-pentachloropyridine

tetrachloromethane

2-fluoropyridine

Downstream raw materials:

3,4,5,6-tetrachloropicolinonitrile

3,5-dichloro-2,4,6-trifluoropyridine

Refernces

• 1、 Froese, Robert D.J.,Whiteker, Gregory T.,Peterson, Thomas H.,Arriola, Daniel J.,Renga, James M.,Shearer, Justin W.. "Computational and Experimental Studies of Regioselective SNAr Halide Exchange (Halex) Reactions of Pentachloropyridine". supporting information. p. 10672 - 10682. Retrieved 2016/11/29.
• 2、 -. "Preparation of 2-cyano-6-chloropyridine compounds". . . Retrieved 2008/06/13.