Methyl 2-methoxypropionate

Base Information

• Chemical Name: Methyl 2-methoxypropionate
• CAS No.: 17639-76-8
• Deprecated CAS: 92935-45-0
• Molecular Formula: C5H10 O3
• Molecular Weight: 118.133
• European Community (EC) Number: 241-622-4
• DSSTox Substance ID: DTXSID20884980
• Nikkaji Number: J287.099A
• Mol file: 17639-76-8.mol

Synonyms:Methyl 2-methoxypropionate;Methyl 2-methoxypropanoate;17639-76-8;Propanoic acid, 2-methoxy-, methyl ester;EINECS 241-622-4;methyl 2-methoxy-propionate;SCHEMBL35974;DTXSID20884980;AMY37763;2-Methoxypropanoic acid methyl ester;MFCD00151664;AKOS005256968;AT18834;BS-21815;CS-0207198;FT-0612867;racemic 2-Methoxy-propionic acid methyl ester;6-Fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylicacid

Chemical Property of Methyl 2-methoxypropionate

Chemical Property:

• Vapor Pressure: 7.45mmHg at 25°C
• Refractive Index: 1.3970
• Boiling Point: 136.2°Cat760mmHg
• Flash Point: 40.6°C
• PSA: 35.53000
• Density: 0.973g/cm³
• LogP: 0.19430
• Water Solubility.: Soluble in water.
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 118.062994177
• Heavy Atom Count: 8
• Complexity: 79.7

Purity/Quality:

98%Min ^*data from raw suppliers

Methyl2-Methoxypropionate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R10:Flammable.; R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: R10:Flammable.; R36/37/38:Irritating to eyes, respiratory system and skin.
• Statements: 11-36/37/38
• Safety Statements: 16-26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(=O)OC)OC
• Uses: Methyl 2-Methoxypropionate is used as a reagent in the synthesis of 2-methoxy-2-methyl-3-{6-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]pyridin-3-yl}propanoic acid which is a dual PPARα/γ agonist. Methyl 2-methoxypropionate, is used as a pharmaceutical intermediate.

Technology Process of Methyl 2-methoxypropionate

There total 23 articles about Methyl 2-methoxypropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.7%

methanol (67-56-1) + methyl lactate (547-64-8,2155-30-8) → methyl 2-methoxypropionate (17639-76-8,92935-45-0)

Guidance literature:

5% by weight NaH2PO4/SiO2; at 260 ℃; for 60h; Product distribution / selectivity; Gas phase;

Reference yield: 90.0%

methanol (67-56-1) + LACTIC ACID (849585-22-4,106989-11-1,26811-96-1,31587-11-8,26100-51-6) + methyl lactate (547-64-8,2155-30-8) → methyl 2-methoxypropionate (17639-76-8,92935-45-0)

Guidance literature:

(0.1% CaHPO4 and 5% K2HPO4)/SiO2; at 300 ℃; for 60h; Product distribution / selectivity; Gas phase;

Reference yield: 50.1%

2-methyl-2,3-pentadiene (3043-33-2) → methyl 2-methoxypropionate (17639-76-8,92935-45-0) + methyl 2-methoxy-2-methylpropanoate (17860-39-8) + 2-Methoxy-4-methyl-4-penten-3-on (57745-55-8) + 2,4-Dimethoxy-2-methyl-pentan-3-one (75075-40-0) + 1,4-Dimethoxy-4-methyl-pentan-3-one (75075-41-1)

Guidance literature:

With lithium perchlorate; In methanol; at 10 ℃; Product distribution; Mechanism; other electrolyte, other electrode, various oxidation potentials, various electricity consumptions, various electrolyte concentrations examined;

DOI:10.1016/0040-4020(82)80146-4

upstream raw materials:

Methyl 2-bromopropionate

sodium methylate

methanol

trans-3-methyloxirane-2-carbaldehyde

Downstream raw materials:

2-methoxy-propionic acid amide

2-methoxypropionic acid

(E)-10-(2,2-Diphenyl-cyclopropyl)-3-hydroxy-2-methoxy-2-methyl-dec-9-enoic acid methyl ester

(E)-9-(2,2-Diphenyl-cyclopropyl)-3-hydroxy-2-methoxy-2-methyl-non-8-enoic acid methyl ester

Refernces

• 1、 Ceroni,Sequin. "Determination of the relative configurations in the side chains of the antibiotics hedamycin and pluramycin A; Synthesis and NMR. Data of suitable model compounds". . p. 302 - 316. Retrieved 1982.
• 2、 -. "PRODUCTION OF ALKYL ESTERS OF ACRYLIC ACID". Page/Page column 7-8. . Retrieved 2020/01/31.
• 3、 Khokarale, Santosh Govind,He, Jian,Schill, Leonhard,Yang, Song,Riisager, Anders,Saravanamurugan, Shunmugavel. "Selective Hydrodeoxygenation of Alkyl Lactates to Alkyl Propionates with Fe-based Bimetallic Supported Catalysts". . p. 681 - 687. Retrieved 2018/02/13.