1-(3,4-dimethoxybenzyl)-4-methoxy-2-(methoxycarbonyl)pyridinium bromide salt

Base Information

• Chemical Name: 1-(3,4-dimethoxybenzyl)-4-methoxy-2-(methoxycarbonyl)pyridinium bromide salt
• CAS No.: 1245527-80-3
• Molecular Formula: Br*C₁₇H₂₀NO₅
• Molecular Weight: 398.254
• Mol file: 1245527-80-3.mol

Synonyms:1-(3,4-dimethoxybenzyl)-4-methoxy-2-(methoxycarbonyl)pyridinium bromide salt

Chemical Property of 1-(3,4-dimethoxybenzyl)-4-methoxy-2-(methoxycarbonyl)pyridinium bromide salt

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 1-(3,4-dimethoxybenzyl)-4-methoxy-2-(methoxycarbonyl)pyridinium bromide salt

There total 1 articles about 1-(3,4-dimethoxybenzyl)-4-methoxy-2-(methoxycarbonyl)pyridinium bromide salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-bromomethyl-1,2-dimethoxybenzene (21852-32-4) + methyl 4-methoxypicolinate (29681-43-4) → 1-(3,4-dimethoxybenzyl)-4-methoxy-2-(methoxycarbonyl)pyridinium bromide salt (1245527-80-3)

Guidance literature:

In diethyl ether; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1016/j.tet.2010.05.044

Reference yield: 93.0%

1-(3,4-dimethoxybenzyl)-4-methoxy-2-(methoxycarbonyl)pyridinium bromide salt (1245527-80-3) + isopropenylmagnesium bromide (13291-18-4) → methyl-1-(3,4-dimethoxybenzyl)-4-oxo-6-(prop-1-en-2-yl)-1,4,5,6-tetrahydropyridine-2-carboxylate (1245527-95-0)

Guidance literature:

1-(3,4-dimethoxybenzyl)-4-methoxy-2-(methoxycarbonyl)pyridinium bromide salt; isopropenylmagnesium bromide; In dichloromethane; at -78 ℃; for 4.58333h; Inert atmosphere;

With hydrogenchloride; In dichloromethane; water; at -78 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2010.05.044

Reference yield: 89.0%

1-(3,4-dimethoxybenzyl)-4-methoxy-2-(methoxycarbonyl)pyridinium bromide salt (1245527-80-3) + 4-methoxyphenyl magnesium bromide (13139-86-1) → methyl-1-(3,4-dimethoxybenzyl)-6-(4-methoxyphenyl)-4-oxo-1,4,5,6-tetrahydropyridine-2-carboxylate (1245527-93-8)

Guidance literature:

1-(3,4-dimethoxybenzyl)-4-methoxy-2-(methoxycarbonyl)pyridinium bromide salt; 4-methoxyphenyl magnesium bromide; In dichloromethane; at -78 ℃; for 4.58333h; Inert atmosphere;

With hydrogenchloride; In dichloromethane; water; at -78 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2010.05.044

upstream raw materials:

4-bromomethyl-1,2-dimethoxybenzene

methyl 4-methoxypicolinate

Downstream raw materials:

methyl-1-(3,4-dimethoxybenzyl)-2-methyl-4-oxo-1,2,3,4-tetrahydropyridine-2-carboxylate

methyl-1-(3,4-dimethoxybenzyl)-2-ethyl-4-oxo-1,2,3,4-tetrahydropyridine-2-carboxylate

methyl-1-(3,4-dimethoxybenzyl)-4-oxo-6-(prop-1-ynyl)-1,4,5,6-tetrahydropyridine-2-carboxylate

methyl-1-(3,4-dimethoxybenzyl)-4-oxo-6-vinyl-1,4,5,6-tetrahydropyridine-2-carboxylate

Refernces