Technology Process of Z(OMe)-(porcine VIP 22-28)-NH2
There total 12 articles about Z(OMe)-(porcine VIP 22-28)-NH2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
triethylamine;
In
N,N,N,N,N,N-hexamethylphosphoric triamide; dimethyl sulfoxide;
at 40 ℃;
for 24h;
DOI:10.1248/cpb.28.1873
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1) Et3N, 2) DCC / 2) DMF, THF, 24 h
2: 80percent hydrazine hydrate / methanol
3: diazotizing reagent
4: 90 percent / Et3N / dimethylsulfoxide; hexamethylphosphoric acid triamide / 40 h / 4 °C
5: 90 percent / Et3N / dimethylsulfoxide; hexamethylphosphoric acid triamide / 40 h / 4 °C
6: TFA, anisole
7: 77 percent / Et3N / dimethylsulfoxide; hexamethylphosphoric acid triamide / 24 h / 40 °C
With
diazotizing reagent; hydrazine hydrate; methoxybenzene; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dimethyl sulfoxide;
DOI:10.1248/cpb.28.1873
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1) Et3N, 2) DCC / 2) DMF, THF, 24 h
2: 80percent hydrazine hydrate / methanol
3: diazotizing reagent
4: 90 percent / Et3N / dimethylsulfoxide; hexamethylphosphoric acid triamide / 40 h / 4 °C
5: 90 percent / Et3N / dimethylsulfoxide; hexamethylphosphoric acid triamide / 40 h / 4 °C
6: TFA, anisole
7: 77 percent / Et3N / dimethylsulfoxide; hexamethylphosphoric acid triamide / 24 h / 40 °C
With
diazotizing reagent; hydrazine hydrate; methoxybenzene; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dimethyl sulfoxide;
DOI:10.1248/cpb.28.1873