4',7-di-O-benzyl-3-O-(β-D-glucopyranosyl)quercetin

Base Information

• Chemical Name: 4',7-di-O-benzyl-3-O-(β-D-glucopyranosyl)quercetin
• CAS No.: 6743-87-9
• Molecular Formula: C₃₅H₃₂O₁₂
• Molecular Weight: 644.632
• Mol file: 6743-87-9.mol

Synonyms:4',7-di-O-benzyl-3-O-(β-D-glucopyranosyl)quercetin

Chemical Property of 4',7-di-O-benzyl-3-O-(β-D-glucopyranosyl)quercetin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4',7-di-O-benzyl-3-O-(β-D-glucopyranosyl)quercetin

There total 7 articles about 4',7-di-O-benzyl-3-O-(β-D-glucopyranosyl)quercetin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-O-(2'',3'',4'',6''-tetra-O-acetyl-β-D-glucopyranosyl)-4',7-di-O-benzyl-3',5-dihydroxyflavonol (131021-81-3) → 4',7-di-O-benzyl-3-O-(β-D-glucopyranosyl)quercetin (6743-87-9)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; for 9.5h; Inert atmosphere;

DOI:10.1080/07328303.2011.616979

Reference yield:

quercetol (117-39-5,74893-81-5) → 4',7-di-O-benzyl-3-O-(β-D-glucopyranosyl)quercetin (6743-87-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: pyridine / 4 h / 140 - 145 °C

2.1: potassium carbonate; potassium iodide / acetone / 120 h / Heating

3.1: sodium hydroxide / water; acetone / 3 h / 0 °C / Inert atmosphere

3.2: 0.5 h / 0 °C / Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 32 h / 20 °C / Inert atmosphere

5.1: sodium methylate / methanol / 9.5 h / 20 °C / Inert atmosphere

With pyridine; sodium methylate; potassium carbonate; potassium iodide; sodium hydroxide; In methanol; water; N,N-dimethyl-formamide; acetone;

DOI:10.1080/07328303.2011.616979

Reference yield:

7,4’-di-O-benzylquercetin (13459-13-7) → 4',7-di-O-benzyl-3-O-(β-D-glucopyranosyl)quercetin (6743-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 32 h / 20 °C / Inert atmosphere

2: sodium methylate / methanol / 9.5 h / 20 °C / Inert atmosphere

With sodium methylate; potassium carbonate; In methanol; N,N-dimethyl-formamide;

DOI:10.1080/07328303.2011.616979

upstream raw materials:

quercetol

7,4’-di-O-benzylquercetin

3,5,7-triacetoxy-2-(3,4-diacetoxy-phenyl)-chromen-4-one

2-(3-acetoxy-4-(benzyloxy) phenyl)-7-(benzyloxy)-4-oxo-4H-chromene-3,5-diyl diacetate

Downstream raw materials:

isoquercetin

Refernces