4--1-chloro-2-(trifluoromethyl)benzene

Base Information

• Chemical Name: 4--1-chloro-2-(trifluoromethyl)benzene
• CAS No.: 144155-72-6
• Molecular Formula: C₁₀H₁₀ClF₃S₂
• Molecular Weight: 286.77
• Mol file: 144155-72-6.mol

Synonyms:4--1-chloro-2-(trifluoromethyl)benzene

Chemical Property of 4--1-chloro-2-(trifluoromethyl)benzene

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4--1-chloro-2-(trifluoromethyl)benzene

There total 1 articles about 4--1-chloro-2-(trifluoromethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-2-chlorobenzotrifluoride (445-01-2) + methyl methylsulfinylmethyl sulfide (33577-16-1) → 4--1-chloro-2-(trifluoromethyl)benzene (144155-72-6)

Guidance literature:

With magnesium; In tetrahydrofuran; for 5h; Ambient temperature;

DOI:10.1021/jm00097a001

Reference yield:

4--1-chloro-2-(trifluoromethyl)benzene (144155-72-6) → 4-chloro-3-(trifluoromethyl)benzaldehyde (34328-46-6)

Guidance literature:

With sulfuryl dichloride; water; silica gel; In chloroform; at 0 ℃; for 2h; Yield given;

DOI:10.1021/jm00097a001

Reference yield:

4--1-chloro-2-(trifluoromethyl)benzene (144155-72-6) → (E)-4-(4-Chloro-3-trifluoromethyl-phenyl)-but-3-en-2-one

Guidance literature:

Multi-step reaction with 2 steps

1: SiO₂, H₂O, SO₂Cl₂ / CHCl₃ / 2 h / 0 °C

2: toluene / 1 h / Heating

With sulfuryl dichloride; water; silica gel; In chloroform; toluene;

DOI:10.1021/jm00097a001

upstream raw materials:

5-bromo-2-chlorobenzotrifluoride

methyl methylsulfinylmethyl sulfide

Downstream raw materials:

4-chloro-3-(trifluoromethyl)benzaldehyde

5-(4-Chloro-3-trifluoromethyl-phenyl)-cyclohexane-1,3-dione

7-Chloro-3-(4-chloro-3-trifluoromethyl-phenyl)-3,4-dihydro-2H,10H-acridine-1,9-dione

7-Chloro-3-(4-chloro-3-trifluoromethyl-phenyl)-1-[(E)-3-dimethylamino-propylimino]-1,3,4,10-tetrahydro-2H-acridin-9-one

Refernces