METHYL 6-HYDROXY-2-NAPHTHOATE

Base Information

• Chemical Name: METHYL 6-HYDROXY-2-NAPHTHOATE
• CAS No.: 17295-11-3
• Molecular Formula: C12H10 O3
• Molecular Weight: 202.21
• Hs Code.: 2918290000
• Mol file: 17295-11-3.mol

Synonyms:2-Naphthoicacid, 6-hydroxy-, methyl ester (8CI); 6-Hydroxynaphthalene-2-carboxylic acidmethyl ester; 6-Methoxycarbonyl-2-naphthol; Methyl 2-hydroxy-6-naphthoate;Methyl 6-hydroxy-2-naphthalenecarboxylate; Methyl 6-hydroxy-2-naphthoate; NSC689401

Chemical Property of METHYL 6-HYDROXY-2-NAPHTHOATE

Chemical Property:

• Vapor Pressure: 6E-06mmHg at 25°C
• Melting Point: 170 °C
• Refractive Index: 1.642
• Boiling Point: 368.5°Cat760mmHg
• PKA: 8.83±0.40(Predicted)
• Flash Point: 163°C
• PSA: 46.53000
• Density: 1.264g/cm³
• LogP: 2.33200
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl 6-Hydroxy-2-naphthoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:
• Hazard Codes: R36/37/38:
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 6-HYDROXY-2-NAPHTHOATE

There total 24 articles about METHYL 6-HYDROXY-2-NAPHTHOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 6-Hydroxy-2-naphthoic acid (16712-64-4) + 2,2-dimethoxy-propane (77-76-9) → methyl 6-hydroxynaphthalene-2-carboxylate (17295-11-3)

Guidance literature:

With hydrogenchloride; In water; at 20 - 55 ℃; for 32h;

Reference yield: 95.0%

methanol (67-56-1) + 6-Hydroxy-2-naphthoic acid (16712-64-4) → methyl 6-hydroxynaphthalene-2-carboxylate (17295-11-3)

Guidance literature:

With sulfuric acid; Reflux;

DOI:10.1055/s-0036-1591746

Reference yield: 66.0%

methyl 6-isopropyl-2-naphthoate (101513-13-7) → methyl 6-isopropenyl-2-naphthoate (958332-47-3) + methyl 6-acetyl-2-naphthoate (33627-00-8) + methyl 6-hydroxynaphthalene-2-carboxylate (17295-11-3)

Guidance literature:

methyl 6-isopropyl-2-naphthoate; With N-hydroxyphthalimide; 2,2'-azobis(isobutyronitrile); oxygen; In acetonitrile; at 75 ℃; for 15h;

With sulfuric acid; In acetonitrile; at 20 ℃; for 1h;

DOI:10.1016/j.tet.2009.03.013

upstream raw materials:

6-benzyloxynaphthalene-2-carboxylic acid methyl ester

methanol

6-Hydroxy-2-naphthoic acid

2-Bromo-6-methoxynaphthalene

Downstream raw materials:

6-Hydroxy-2-naphthoic acid

N'-(3,5-dibromo-2,4-dihydroxybenzylidene)-6-(methylsulfonyl)-2-naphthohydrazide

methyl 2-(4-methoxyphenyl)-2-methyl-1,2-dihydronaphtho[2,1-b]furan-7-carboxylate

4-[6-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-naphthalen-2-ylmethoxy]-benzoic acid

Refernces

• 1、 Chakraborty, Soumen,Mal, Dipakranjan. "C -Glycosylation of Substituted β-Naphthols with Trichloroacetimidate Glycosyl Donors". . p. 1560 - 1568. Retrieved 2018.
• 2、 Jiao, Shaoshao,Li, Shaoxiang,Liu, Kang,Ma, Dingxuan,Wang, Lei,Yang, Bo,Zhang, Xinghao,Zhang, Yaowen. "Construction, structure diversity, luminescent and dye absorption properties of coordination polymers comprising semi-rigid 6-(carboxymethoxy)-2-naphthoic acid". . . Retrieved 2021.
• 3、 Schramm, Simon,Agnetta, Luca,Bermudez, Marcel,Gerwe, Hubert,Irmen, Matthias,Holze, Janine,Littmann, Timo,Wolber, Gerhard,Tr?nkle, Christian,Decker, Michael. "Novel BQCA- and TBPB-Derived M1 Receptor Hybrid Ligands: Orthosteric Carbachol Differentially Regulates Partial Agonism". supporting information. p. 1349 - 1358. Retrieved 2019/07/12.