6-CHLORO-4-HYDROXY-2-PHENYLQUINOLINE

Base Information

• Chemical Name: 6-CHLORO-4-HYDROXY-2-PHENYLQUINOLINE
• CAS No.: 17282-72-3
• Molecular Formula: C15H10 Cl N O
• Molecular Weight: 255.703
• Hs Code.: 2933499090
• Mol file: 17282-72-3.mol

Synonyms:OTAVA-BB BB7018670039;6-CHLORO-4-HYDROXY-2-PHENYLQUINOLINE

Chemical Property of 6-CHLORO-4-HYDROXY-2-PHENYLQUINOLINE

Chemical Property:

• Boiling Point: 421.8°Cat760mmHg
• Flash Point: 208.9°C
• PSA: 33.12000
• Density: 1.303g/cm³
• LogP: 4.26080
• Storage Temp.: 2-8°C

Purity/Quality:

98.5% ^*data from raw suppliers

6-Chloro-2-phenylquinolin-4-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-CHLORO-4-HYDROXY-2-PHENYLQUINOLINE

There total 7 articles about 6-CHLORO-4-HYDROXY-2-PHENYLQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

6-Chloro-2-phenyl-4-(toluene-4-sulfonyl)-quinoline (204913-35-9) → 6-chloro-2-phenyl-quinolin-4-ol (17282-72-3)

Guidance literature:

With sodium hydroxide; In water; dimethyl sulfoxide; at 50 ℃; for 48h;

DOI:10.1016/S0040-4020(98)00023-4

Reference yield:

ethyl 3-oxo-3-phenylpropionate (94-02-0) + 4-chloro-aniline (106-47-8) → 6-chloro-2-phenyl-quinolin-4-ol (17282-72-3)

Guidance literature:

With hydrogenchloride; water; und Behandeln des Reaktionsprodukts mit konz. Schwefelsaeure und Acetanhydrid;

Reference yield:

ethyl 3-oxo-3-phenylpropionate (94-02-0) + 4-chloro-aniline (106-47-8) → 6-Chloro-2-phenyl-7-quinolinol + 6-chloro-2-phenyl-quinolin-4-ol (17282-72-3)

Guidance literature:

upstream raw materials:

ethyl 3-oxo-3-phenylpropionate

4-chloro-aniline

6-Chloro-2-phenyl-4-(toluene-4-sulfonyl)-quinoline

4-chlorobenzonitrile

Downstream raw materials:

4,6-dichloro-2-phenylquinoline

Refernces

• 1、 Huang, Guang,Murillo Solano, Claribel,Melendez, Joel,Shaw, Justin,Collins, Jennifer,Banks, Robert,Arshadi, Arash Keshavarzi,Boonhok, Rachasak,Min, Hui,Miao, Jun,Chakrabarti, Debopam,Yuan, Yu. "Synthesis, Structure-Activity Relationship, and Antimalarial Efficacy of 6-Chloro-2-arylvinylquinolines". . p. 11756 - 11785. Retrieved 2020/11/26.
• 2、 Desai,Desai, Pratibha,Machhi, Dilip,Desai,Patel, Dinesh. "Quinoline derivatives as antitubercular/antibacterial agents". . p. 871 - 873. Retrieved 2007/10/03.