leucyl-alanyl-glycyl-valine

Base Information

• Chemical Name: leucyl-alanyl-glycyl-valine
• CAS No.: 17195-26-5
• Molecular Formula: C₁₆H₃₀N₄O₅
• Molecular Weight: 358.438
• Mol file: 17195-26-5.mol

Synonyms:L-Valine,N-[N-(N-L-leucyl-L-alanyl)glycyl]-; Valine, N-[N-(N-L-leucyl-L-alanyl)glycyl]-(7CI); Valine, N-[N-(N-L-leucyl-L-alanyl)glycyl]-, L- (8CI); 10: PN: EP1466612PAGE: 13 unclaimed sequence; 10: PN: US20030219425 SEQID: 10 claimed sequence;10: PN: US20080171094 SEQID: 10 claimed protein; 10: PN: US20080194489 SEQID:10 claimed protein; 10: PN: US20080242837 SEQID: 10 claimed protein; 11: PN:EP1466613 PAGE: 9 unclaimed sequence; 11: PN: US20030215434 PAGE: 4 unclaimedsequence; 11: PN: WO2005046569 SEQID: 11 claimed protein; 11: PN: WO2009014440PAGE: 2 claimed protein; 13: PN: EP1300418 SEQID: 13 claimed protein; 26: PN:US20050037430 SEQID: 26 claimed sequence; 37: PN: WO03029292 PAGE: 124 claimedprotein; 40: PN: US20030119720 PAGE: 6 unclaimed sequence; 4: PN: US20060142205SEQID: 4 claimed sequence; 6: PN: US20040202645 SEQID: 10 unclaimed sequence;8: PN: US20030220257 SEQID: 10 unclaimed sequence; 8: PN: US20030220258 SEQID:10 unclaimed sequence; 8: PN: US20030220261 SEQID: 10 unclaimed sequence; 8:PN: US20030224995 SEQID: 10 unclaimed protein; H-Leu-Ala-Gly-Val-OH;L-Leucyl-L-alanylglycyl-L-valine

Chemical Property of leucyl-alanyl-glycyl-valine

Chemical Property:

• Vapor Pressure: 4E-21mmHg at 25°C
• Refractive Index: 1.503
• Boiling Point: 694.6°C at 760 mmHg
• Flash Point: 373.9°C
• PSA: 161.09000
• Density: 1.153g/cm³
• LogP: 2.42730

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of leucyl-alanyl-glycyl-valine

There total 24 articles about leucyl-alanyl-glycyl-valine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

→ Leu-Ala-Gly-Val (17195-26-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In N,N-dimethyl-formamide; at 25 ℃; for 0.0833333h;

DOI:10.1016/S0040-4039(00)95763-0

Reference yield: 85.0%

Fmoc-Leu-Ala-Gly-Val-OBzl (209910-45-2) → Leu-Ala-Gly-Val (17195-26-5)

Guidance literature:

With formic acid; palladium; In methanol; for 3h; Ambient temperature;

DOI:10.1080/00397919908085738

Reference yield: 20.0%

L-alanin (56-41-7,25191-17-7,18875-37-1) + L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) + Smoc-Leu-OH + glycine (56-40-6,18875-39-3,25718-94-9) → Leu-Ala-Gly-Val (17195-26-5)

Guidance literature:

Smoc-Leu-OH; With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water; isopropyl alcohol;

L-alanin; In water; at 25 ℃; for 0.166667h; pH=7;

L-valine; glycine; Further stages;

upstream raw materials:

L-Valine methyl ester

N-(fluoren-9-ylmethoxycarbonyl)glycine

Fmoc-Leu-OH

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Refernces

• 1、 Coleman, Daniel R.,Royer, Garfield P.. "New Hydrogenation Catalyst: Palladium-Poly(ethylenimine) "Ghosts". Applications in Peptide Synthesis". . p. 2268 - 2269. Retrieved 1980.
• 2、 Merrifield. "". . p. 2149,2152,2154. Retrieved 1963.
• 3、 -. "Treatment for tumors". Page/Page column 8. . Retrieved 2010/11/25.
• 4、 -. "Treatment of inflammation and sepsis with hCG derived peptides". Page/Page column 9. . Retrieved 2008/06/13.