1H,3H-Naphthol[1,8-cd]pyran-1,3dione,6-methoxy-

Base Information

• Chemical Name: 1H,3H-Naphthol[1,8-cd]pyran-1,3dione,6-methoxy-
• CAS No.: 17190-36-2
• Molecular Formula: C₁₃H₈O₄
• Molecular Weight: 228.204
• Mol file: 17190-36-2.mol

Synonyms:Naphthalicanhydride, 4-methoxy- (8CI); 4-Methoxy-1,8-naphthalenedicarboxylic anhydride

Chemical Property of 1H,3H-Naphthol[1,8-cd]pyran-1,3dione,6-methoxy-

Chemical Property:

• PSA: 52.60000
• LogP: 2.15900

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Use Description: 1H,3H-Naphthol[1,8-cd]pyran-1,3dione,6-methoxy-, is a chemical compound with potential applications in various fields. In the pharmaceutical and medicinal chemistry sector, it serves as an important intermediate in the synthesis of compounds with potential therapeutic properties. Its role is pivotal in the structural modification of molecules, allowing the creation of novel drug candidates targeting specific biological pathways or receptors, potentially leading to the development of new medications. Additionally, in the field of academic research and organic chemistry, this compound can be used as a versatile building block for the synthesis of complex organic molecules, aiding in the study of chemical reactions and the development of new chemical methodologies. Its versatility across these fields underscores its significance in drug discovery, academic research, and the advancement of chemical science, potentially contributing to healthcare and scientific knowledge.

Technology Process of 1H,3H-Naphthol[1,8-cd]pyran-1,3dione,6-methoxy-

There total 12 articles about 1H,3H-Naphthol[1,8-cd]pyran-1,3dione,6-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

Spiro<(5-methoxyacenaphthen-1-one)-2,2'-(5,5'-dimethyl-1',3'-dioxane)> (215931-06-9) → 6-Methoxy-1,2-naphtho<1,8-cd>pyran-1,3-dione (17190-36-2) + 5-methoxy-acenaphthylene-1,2-dione

Guidance literature:

With sulfuric acid; water; In tetrahydrofuran; at 60 ℃; for 1.5h;

Reference yield:

5-chloro-acenaphthene-1,2-dione (13383-81-8) → 6-Methoxy-1,2-naphtho<1,8-cd>pyran-1,3-dione (17190-36-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 20 percent / p-TsOH / benzene / 2 h / Heating

2: 100 percent / MeONa / Heating

3: 10 percent / H₂SO₄, H₂O / tetrahydrofuran / 1.5 h / 60 °C

With sulfuric acid; water; sodium methylate; toluene-4-sulfonic acid; In tetrahydrofuran; benzene;

Reference yield:

5-bromoacenaphthylene-1,2-dione (26254-35-3) → 6-Methoxy-1,2-naphtho<1,8-cd>pyran-1,3-dione (17190-36-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 20 percent / p-TsOH / benzene / 4 h / Heating

2: 100 percent / MeONa / 6.5 h / Heating

3: 10 percent / H₂SO₄, H₂O / tetrahydrofuran / 1.5 h / 60 °C

With sulfuric acid; water; sodium methylate; toluene-4-sulfonic acid; In tetrahydrofuran; benzene;

upstream raw materials:

acenaphthen-5-yl-methyl ether

7-methoxy-phenalen-1-one

4-methoxy-9,10-dihydro-8H-cyclohepta[de]naphthalen-7-one

Spiro<(5-methoxyacenaphthen-1-one)-2,2'-(5,5'-dimethyl-1',3'-dioxane)>

Downstream raw materials:

4-methoxy-N-phenyl-1,8-naphthalimide

Refernces