NSC 18751

Base Information

• Chemical Name: NSC 18751
• CAS No.: 6966-21-8
• Molecular Formula: C16H16 O2
• Molecular Weight: 240.302
• Mol file: 6966-21-8.mol

Synonyms:4-Hydroxy-2'-phenylbutyrophenone;NSC 18751

Chemical Property of NSC 18751

Chemical Property:

• Vapor Pressure: 2.47E-07mmHg at 25°C
• Boiling Point: 410.8°Cat760mmHg
• Flash Point: 175.4°C
• PSA: 37.30000
• Density: 1.123g/cm³
• LogP: 3.76870
• Solubility.: Acetone, DIchloromethane

Purity/Quality:

99.9% ^*data from raw suppliers

1-(4-Hydroxyphenyl)-2-phenyl-1-butanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An intermediate for the synthesis of Tamoxifen

Technology Process of NSC 18751

There total 5 articles about NSC 18751 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.5%

1-(4-benzyloxyphenyl)-2-phenyl-butan-1-one (70354-03-9) → 1-(4'-hydroxyphenyl)-2-phenyl-n-butane-1-one (6966-21-8)

Guidance literature:

With hydrogen bromide; acetic acid; In acetic acid;

Reference yield: 76.0%

methoxybenzene (100-66-3) + 2-Phenylbutyric acid (90-27-7) → 1-(4'-hydroxyphenyl)-2-phenyl-n-butane-1-one (6966-21-8)

Guidance literature:

methoxybenzene; 2-Phenylbutyric acid; With trifluoroacetic anhydride; In toluene; at 10 - 40 ℃; for 73h;

With sodium hydroxide; In water; toluene; at 20 - 35 ℃; for 1h; pH=10;

aluminum (III) chloride; In toluene; at 70 ℃; for 1h;

Reference yield:

1-(4-methoxyphenyl)-2-phenylbutan-1-one (78423-10-6) → 1-(4'-hydroxyphenyl)-2-phenyl-n-butane-1-one (6966-21-8)

Guidance literature:

With sodium hydroxide; pyridine hydrochloride;

upstream raw materials:

1-(4-methoxyphenyl)-2-phenylbutan-1-one

1-(4-benzyloxyphenyl)-2-phenyl-butan-1-one

1-(4-Hydroxyphenyl)-2-phenylethanone

4-(benzyloxy)phenyl benzyl ketone

Downstream raw materials:

1-[4-(2-diethylamino-ethoxy)-phenyl]-2-phenyl-butan-1-one

C₃₆H₄₄O₄Si

C₂₂H₃₀O₂Si

1-<4-<(tetrahydropyran-2-yl)oxy>phenyl>-2-phenylbutan-1-one

Refernces

• 1、 -. "1,1,2-TRIPHENYLBUT-1-ENE DERIVATIVES". . . Retrieved 2008/06/13.