Technology Process of 3,4-dimethoxy-9-(3',4',5'-trimethoxyphenyl)-6,7-dihydro-5H-benzo[7]annulene
There total 5 articles about 3,4-dimethoxy-9-(3',4',5'-trimethoxyphenyl)-6,7-dihydro-5H-benzo[7]annulene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
1.2: 0 - 20 °C
2.1: hydrogen / palladium 10% on activated carbon / methanol / 24 h
3.1: methanesulfonic acid; phosphorus pentoxide / 12 h / Inert atmosphere
4.1: n-butyllithium / tetrahydrofuran; hexanes / 1 h / -78 °C
4.2: -78 - 20 °C
4.3: 20 °C
5.1: acetic acid / 4 h / Reflux
With
n-butyllithium; methanesulfonic acid; phosphorus pentoxide; potassium tert-butylate; hydrogen; acetic acid;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; hexanes;
1.1: Wittig Reaction;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogen / palladium 10% on activated carbon / methanol / 24 h
2.1: methanesulfonic acid; phosphorus pentoxide / 12 h / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexanes / 1 h / -78 °C
3.2: -78 - 20 °C
3.3: 20 °C
4.1: acetic acid / 4 h / Reflux
With
n-butyllithium; methanesulfonic acid; phosphorus pentoxide; hydrogen; acetic acid;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; hexanes;
![1,2-dimethoxy-5-(3',4',5'-trimethoxyphenyl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol](/Databaselist/images/loading.webp)
