2-NAPHTHYLSULFONYLHYDRAZIDE

Base Information

• Chemical Name: 2-NAPHTHYLSULFONYLHYDRAZIDE
• CAS No.: 10151-46-9
• Molecular Formula: C10H10 N2 O2 S
• Molecular Weight: 222.268
• Hs Code.: 2935009090
• Mol file: 10151-46-9.mol

Synonyms:(b-Naphthylsulfonyl)hydrazine;2-Naphthalenesulfonyl hydrazide; 2-Naphthylsulfonyl hydrazide;N-(2-Naphthylsulfonyl)hydrazine; NSC 274887

Chemical Property of 2-NAPHTHYLSULFONYLHYDRAZIDE

Chemical Property:

• Vapor Pressure: 6.94E-08mmHg at 25°C
• Melting Point: 131 °C(Solv: ethanol (64-17-5))
• Boiling Point: 438.4°Cat760mmHg
• PKA: 9.45±0.40(Predicted)
• Flash Point: 218.9°C
• PSA: 80.57000
• Density: 1.377g/cm³
• LogP: 3.16380

Purity/Quality:

98%,99%, ^*data from raw suppliers

Naphthalene-2-sulfonohydrazide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Naphthalene-2-sulfonohydrazide is a reagent used in the preparation of sulfonated pyrazoles which may be useful in the discovery of antibacterial agents.

Technology Process of 2-NAPHTHYLSULFONYLHYDRAZIDE

There total 2 articles about 2-NAPHTHYLSULFONYLHYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Naphthalenesulfonyl chloride (93-11-8) → 2-naphthylsulfonyl hydrazide (10151-46-9)

Guidance literature:

With hydrazine hydrate; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1021/acs.jmedchem.9b00665

Reference yield:

→ 2-naphthylsulfonyl hydrazide (10151-46-9)

Guidance literature:

Naphthalin-2-sulfonylchlorid, Hydrazin-hydrat, Me.;

Reference yield: 99.0%

2-naphthylsulfonyl hydrazide (10151-46-9) → 2-Naphthalenesulfonyl chloride (93-11-8)

Guidance literature:

With N-chloro-succinimide; In acetonitrile; at 20 ℃; for 2h;

DOI:10.3390/molecules26185551

upstream raw materials:

2-Naphthalenesulfonyl chloride

Downstream raw materials:

naphthalene-2-sulfinic acid

hydrazine

benzaldehyde (2-naphthylsulfonyl)hydrazone

anisaldehyde (2-naphthylsulfonyl)hydrazone

Refernces

• 1、 Jiang, Huanfeng,Yan, Wuxin,Huang, Jiuzhong,Tan, Chaowei,Zhan, Lingzhi,Wu, Wanqing. "Palladium-Catalyzed Regio- and Stereoselective Sulfonylation of Aryl Propiolates with Sulfonyl Hydrazides: Access to (E)-β-Aryl Sulfonyl Acrylates". . p. 4575 - 4580. Retrieved 2019.
• 2、 Wang, Bin,Tang, Lin,Liu, Liyan,Li, Yanan,Yang, Yu,Wang, Zhiyong. "Base-mediated tandem sulfonylation and oximation of alkenes in water". . p. 5794 - 5799. Retrieved 2017.
• 3、 Priebbenow, Daniel L.,Leaver, David J.,Nguyen, Nghi,Cleary, Benjamin,Lagiakos, H. Rachel,Sanchez, Julie,Xue, Lian,Huang, Fei,Sun, Yuxin,Mujumdar, Prashant,Mudududdla, Ramesh,Varghese, Swapna,Teguh, Silvia,Charman, Susan A.,White, Karen L.,Shackleford, David M.,Katneni, Kasiram,Cuellar, Matthew,Strasser, Jessica M.,Dahlin, Jayme L.,Walters, Michael A.,Street, Ian P.,Monahan, Brendon J.,Jarman, Kate E.,Jousset Sabroux, Helene,Falk, Hendrik,Chung, Matthew C.,Hermans, Stefan J.,Downer, Natalie L.,Parker, Michael W.,Voss, Anne K.,Thomas, Tim,Baell, Jonathan B.. "Discovery of acylsulfonohydrazide-derived inhibitors of the lysine acetyltransferase, kat6a, as potent senescence-inducing anti-cancer agents". . p. 4655 - 4684. Retrieved 2020.
• 4、 Siemann, Stefan,Evanoff, Darryl P.,Marrone, Laura,Clarke, Anthony J.,Viswanatha, Thammaiah,Dmitrienko, Gary I.. "N-arylsulfonyl hydrazones as inhibitors of IMP-1 metallo-β-lactamase". . p. 2450 - 2457. Retrieved 2002.
• 5、 Zhao, Bin,Pan, Zichen,Zhu, Anqiao,Yue, Yanni,Ma, Mengtao,Xue, Fei. "Electrochemical fluorosulfonylation of alkenes to access vicinal fluorinated sulfones derivatives". supporting information. . Retrieved 2022/01/24.
• 6、 Ye, Zhi-Peng,Gao, Jie,Duan, Xin-Yu,Guan, Jian-Ping,Liu, Fang,Chen, Kai,Xiao, Jun-An,Xiang, Hao-Yue,Yang, Hua. "Electrochemical heterodifunctionalization of α-CF3alkenes to access α-trifluoromethyl-β-sulfonyl tertiary alcohols". supporting information. p. 8969 - 8972. Retrieved 2021/09/10.