N-ETHOXYCARBONYL-5-NITRO-O-TOLUIDINE

Base Information

• Chemical Name: N-ETHOXYCARBONYL-5-NITRO-O-TOLUIDINE
• CAS No.: 16648-52-5
• Molecular Formula: C10H12 N2 O4
• Molecular Weight: 224.21
• Hs Code.: 2924299090
• Mol file: 16648-52-5.mol

Synonyms:Carbamicacid, (2-methyl-5-nitrophenyl)-, ethyl ester (9CI); Carbanilic acid,2-methyl-5-nitro-, ethyl ester (8CI); Ethyl 2-methyl-5-nitrophenylcarbamate

Chemical Property of N-ETHOXYCARBONYL-5-NITRO-O-TOLUIDINE

Chemical Property:

• Melting Point: 135 °C
• Boiling Point: 297.7oC at 760 mmHg
• Flash Point: 133.8oC
• PSA: 84.15000
• Density: 1.292g/cm3
• LogP: 3.06780

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Ethoxycarbonyl-5-nitro-o-toluidine >96.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-ETHOXYCARBONYL-5-NITRO-O-TOLUIDINE

There total 6 articles about N-ETHOXYCARBONYL-5-NITRO-O-TOLUIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-bromo-4-nitrotoluene (7745-93-9) + urethane (51-79-6) → ethyl (2-methyl-5-nitrophenyl)carbamate (16648-52-5)

Guidance literature:

With ?di-tert-butyl(2,2-diphenyl-1-methyl-1-cyclopropyl)phosphine; bis(η3-allyl-μ-chloropalladium(II)); triisopropylsilanol; potassium hydroxide; In water; at 50 ℃; for 24h; Inert atmosphere; Green chemistry;

DOI:10.1039/c3gc42188k

Reference yield:

chloroformic acid ethyl ester (541-41-3) + 2-methyl-5-nitroaniline (99-55-8) → ethyl (2-methyl-5-nitrophenyl)carbamate (16648-52-5)

Guidance literature:

Reference yield:

2-methyl-5-nitrophenyl isocyanate (13471-68-6) → ethyl (2-methyl-5-nitrophenyl)carbamate (16648-52-5)

Guidance literature:

With ethanol;

upstream raw materials:

2-methyl-5-nitrophenyl isocyanate

chloroformic acid ethyl ester

2-methyl-5-nitroaniline

o-toluidine

Downstream raw materials:

carbamic acid, (5-amino-2-methyphenyl)-, ethyl ester

Refernces

• 1、 Owen, Stephen,Otani, Takahito,Masaoka, Satoshi,Ohe, Tatsuhiko. "The Biodegradation of Low-molecular-weight Urethane Compounds by a Strain of Exophiala jeanselmei". . p. 244 - 248. Retrieved 2007/10/03.