S-[2-(4-fluorophenyl)-2-oxoethyl]-O-ethyl dithiocarbonate

Base Information

• Chemical Name: S-[2-(4-fluorophenyl)-2-oxoethyl]-O-ethyl dithiocarbonate
• CAS No.: 128400-42-0
• Molecular Formula: C₁₁H₁₁FO₂S₂
• Molecular Weight: 258.338
• Mol file: 128400-42-0.mol

Synonyms:S-[2-(4-fluorophenyl)-2-oxoethyl]-O-ethyl dithiocarbonate

Chemical Property of S-[2-(4-fluorophenyl)-2-oxoethyl]-O-ethyl dithiocarbonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of S-[2-(4-fluorophenyl)-2-oxoethyl]-O-ethyl dithiocarbonate

There total 5 articles about S-[2-(4-fluorophenyl)-2-oxoethyl]-O-ethyl dithiocarbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

→ S-[2-(4-fluorophenyl)-2-oxoethyl]-O-ethyl dithiocarbonate (128400-42-0)

Guidance literature:

Reference yield: 96.0%

potassium ethyl xanthogenate (140-89-6) + 2-bromo-4'-fluoroacetophenone (403-29-2) → S-[2-(4-fluorophenyl)-2-oxoethyl]-O-ethyl dithiocarbonate (128400-42-0)

Guidance literature:

2-bromo-4'-fluoroacetophenone; With sodium iodide; In acetone; at 20 ℃; for 0.166667h;

potassium ethyl xanthogenate; In acetone; at 20 ℃; for 0.333333h;

DOI:10.1039/c9ob00701f

Reference yield: 90.0%

1-(4-fluorophenyl)-2-diazoethan-1-one (3488-44-6) + potassium ethyl xanthogenate (140-89-6) → S-[2-(4-fluorophenyl)-2-oxoethyl]-O-ethyl dithiocarbonate (128400-42-0)

Guidance literature:

1-(4-fluorophenyl)-2-diazoethan-1-one; With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃;

potassium ethyl xanthogenate; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1055/a-1513-9968

upstream raw materials:

potassium ethyl xanthogenate

2-bromo-4'-fluoroacetophenone

sodium O-ethyl dithiocarbonate

1-(4-fluorophenyl)-2-diazoethan-1-one

Downstream raw materials:

(E)-4-(4-chloro-phenyl)-7-(4-fluoro-phenyl)-7-oxo-hept-2-enoic acid ethyl ester

2-(4-fluorophenyl)thiophene

4-[3-(4-fluorophenyl)-3-oxopropyl][1,3]dithietan-2-one

S-1-(N-(4-acetamido-3,5,6-trifluoropyridin-2-yl)acetamido)-5-(4-fluorophenyl)-5-oxopentan-2-yl O-ethyl carbonodithioate

Refernces

• 1、 López-López, Ernesto Emmanuel,López-Jiménez, Sergio J.,Barroso-Flores, Joaquín,Rodríguez-Cárdenas, Esdrey,Tapia-Tapia, Melina,López-Téllez, Gustavo,Miranda, Luis D.,Frontana-Uribe, Bernardo A.. "Electrochemical reactivity of S-phenacyl-O-ethyl-xanthates in hydroalcoholic (MeOH/H2O 4:1) and anhydrous acetonitrile media". . . Retrieved 2021/04/12.
• 2、 Jullien, Helene,Quiclet-Sire, Beatrice,Tetart, Thomas,Zard, Samir Z.. "Flexible routes to thiophenes". supporting information. p. 302 - 305. Retrieved 2014/01/23.