4-chloro-6-(trifluoromethyl)quinazoline

Base Information

• Chemical Name: 4-chloro-6-(trifluoromethyl)quinazoline
• CAS No.: 16499-64-2
• Molecular Formula: C9H4ClF3N2
• Molecular Weight: 232.592
• Hs Code.: 2933990090
• Mol file: 16499-64-2.mol

Synonyms:4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline

Chemical Property of 4-chloro-6-(trifluoromethyl)quinazoline

Chemical Property:

• Appearance/Colour: white or almost white power
• Refractive Index: 1.558
• Boiling Point: 285.815 °C at 760 mmHg
• PKA: -0.01±0.30(Predicted)
• Flash Point: 126.657 °C
• PSA: 25.78000
• Density: 1.496 g/cm³
• LogP: 3.30200
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-Chloro-6-trifluoromethyl-quinazoline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-6-(trifluoromethyl)quinazoline

There total 3 articles about 4-chloro-6-(trifluoromethyl)quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(trifluoromethyl)-3Η-quinazolin-4-one (16544-67-5) → 4-chloro-6-(trifluoromethyl)quinazoline (16499-64-2)

Guidance literature:

With phosphorus pentachloride; In 1,2-dichloro-ethane; at 170 ℃; for 1.66667h; Microwave irradiation;

Reference yield:

6-(trifluoromethyl)quinazolin-4-ol (16544-67-5) → 4-chloro-6-(trifluoromethyl)quinazoline (16499-64-2)

Guidance literature:

With trichlorophosphate; for 3h; Heating / reflux;

Reference yield:

→ 4-chloro-6-(trifluoromethyl)quinazoline (16499-64-2)

Guidance literature:

6-Trifluormethyl-3,4-dihydro-4-oxo-chinazolin, PCl5, Phosphorxychlorid, Δ;

DOI:10.1039/j29670000449

upstream raw materials:

6-(trifluoromethyl)quinazolin-4-ol

6-(trifluoromethyl)-3Η-quinazolin-4-one

Downstream raw materials:

benzyl (2S,3S)-3-hydroxy-2-(2-(6-(trifluoromethyl)quinazolin-4-ylamino)acetamido)hex-4-ynylcarbamate

C₂₄H₃₂F₃N₅O

C₂₅H₃₄F₃N₅O₂

Refernces

• 1、 -. "COMPOUNDS USEFUL AS ANTAGONISTS OF CCR2". Page/Page column 95. . Retrieved 2008/06/13.
• 2、 -. "Lactams of alkylated acyclic diamine derivatives as modulators of chemokine receptor activity". Page/Page column 29-30. . Retrieved 2010/02/10.