N-{1-[3-(2-ethoxyphenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}butyroamide

Base Information

• Chemical Name: N-{1-[3-(2-ethoxyphenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}butyroamide
• CAS No.: 927690-90-2
• Molecular Formula: C₁₇H₂₂N₄O₃
• Molecular Weight: 330.387
• Mol file: 927690-90-2.mol

Synonyms:N-{1-[3-(2-ethoxyphenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}butyroamide

Chemical Property of N-{1-[3-(2-ethoxyphenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}butyroamide

Chemical Property:

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-{1-[3-(2-ethoxyphenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}butyroamide

There total 11 articles about N-{1-[3-(2-ethoxyphenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}butyroamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-ethoxy-benzamidine hydrochloride (18637-00-8) + ethyl 3-butyramido-2-oxobutyrate (68282-26-8) → N-{1-[3-(2-ethoxyphenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}butyroamide (927690-90-2)

Guidance literature:

2-ethoxy-benzamidine hydrochloride; With hydrazine hydrate; In ethanol; at 20 ℃; Cooling with ice;

ethyl 3-butyramido-2-oxobutyrate; In ethanol; Reflux;

Reference yield: 28.4%

2-Ethoxybenzamidine (53623-81-7) + ethyl 3-butyramido-2-oxobutyrate (68282-26-8) → N-{1-[3-(2-ethoxyphenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}butyroamide (927690-90-2)

Guidance literature:

2-Ethoxybenzamidine; With hydrazine hydrate; In ethanol; at 20 ℃;

ethyl 3-butyramido-2-oxobutyrate; In ethanol; for 3.25h; Reflux;

Reference yield:

C10H17NO4 + 2-ethoxy-benzamidine hydrochloride (18637-00-8) → N-{1-[3-(2-ethoxyphenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}butyroamide (927690-90-2)

Guidance literature:

2-ethoxy-benzamidine hydrochloride; With hydrazine; In methanol; at 0 ℃; for 0.166667h;

C₁₀H₁₇NO₄; In methanol; for 4h; Heating / reflux;

upstream raw materials:

ethyl 3-butyramido-2-oxobutyrate

2-ethoxybenzimidohydrazide

2-butyrylaminopropionic acid

2-ethoxybenzonitrile

Downstream raw materials:

2-(2-ethoxyphenyl)-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one

C₁₇H₂₁ClN₄O₅S

4-(5-thioxo-5H-1,2-dithiol-3-yl)phenyl 2-(4-(4-ethoxy-3-(5-methyl-4-oxo-7-propyl-1,4-dihydroimidazo[1,5-f][1,2,4]triazin-2-yl)phenylsulfonyl)piperazin-1-yl)acetate

2-(4-(4-ethoxy-3-(5-methyl-4-oxo-7-propyl-1,4-dihydroimidazo[1,5-f][1,2,4]triazin-2-yl)phenylsulfonyl)piperazin-1-yl)acetic acid

Refernces

• 1、 -. "NOVEL COMPOUNDS AS DUAL INHIBITORS OF PHOSPHODIESTERASES AND HISTONE DEACETYLASES". . . Retrieved 2014/09/16.
• 2、 -. "N-BUTYRAMIDE, THE PREPARATION METHOD AND USE THEREOF". . . Retrieved 2011/08/08.