2-Methylproline hydrochloride

Base Information

• Chemical Name: 2-Methylproline hydrochloride
• CAS No.: 16277-06-8
• Molecular Formula: C₆H₁₁NO₂
• Molecular Weight: 129.159
• Hs Code.: 2933990090
• European Community (EC) Number: 804-948-3,868-193-1
• Mol file: 16277-06-8.mol

Synonyms:2-METHYLPROLINE HYDROCHLORIDE;1423025-85-7;2-methylpyrrolidine-2-carboxylic acid hydrochloride;2-Methyl-DL-proline HCl;2-Methylprolinehydrochloride;2-methylpyrrolidine-2-carboxylic acid;hydrochloride;16277-06-8;SCHEMBL17393208;MFCD22565928;AKOS026742792;AT21800;BS-40253;SY098797;CS-0197811;FT-0774761;EN300-114790;2-Methylproline hydrochloride (H-DL-aMePro-OH);A1-02095;Z1483991628;S)-2-Methylpyrrolidine-2-carboxylic acid (Hydrochloride);(S)-2-methylpyrrolidine-2-carboxylic acid Hydrochloride;2-Methyl-L-proline hydrochloride;(2S)-2-methylpyrrolidine-2-carboxylic acid hydrochloride;2-methyl-L-proline HCl

Chemical Property of 2-Methylproline hydrochloride

Chemical Property:

• PSA: 49.33000
• LogP: 0.54190
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 165.0556563
• Heavy Atom Count: 10
• Complexity: 135

Purity/Quality:

99% ^*data from raw suppliers

2-methylproline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CCCN1)C(=O)O.Cl

Technology Process of 2-Methylproline hydrochloride

There total 9 articles about 2-Methylproline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

DL-(α-methyl)proline amide (848488-83-5) → α-methylproline (16277-06-8)

Guidance literature:

With sulfuric acid; water; for 5h; Reflux;

Reference yield:

5-chloro-2-pentanone (5891-21-4) → α-methylproline (16277-06-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ammonium acetate / water; tert-butyl alcohol / 2.5 h / 50 °C

1.2: 2.5 h

1.3: 24 h / 15 - 20 °C

2.1: sulfuric acid; water / 5 h / Reflux

With sulfuric acid; ammonium acetate; water; In water; tert-butyl alcohol;

Reference yield:

(1S)-N-(1'-phenylethyl)-α-methylprolinamide → α-methylproline (16277-06-8)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen; acetic acid / ethyl acetate; methanol / 4.5 h / 60 °C

2: sulfuric acid; water / 5 h / Reflux

With sulfuric acid; palladium 10% on activated carbon; water; hydrogen; acetic acid; In methanol; ethyl acetate;

upstream raw materials:

DL-(α-methyl)proline amide

5-chloro-2-pentanone

1-benzyl-2-methylpyrrolidine-2-carbonitrile

1-benzyl-2-methylpyrrolidine-2-carboxamide

Downstream raw materials:

(2-methylpyrrolidin-2-yl)methanol

Refernces

• 1、 -. "Α-substd. provitamin optically active production of phosphorus". Paragraph 0232. . Retrieved 2016/12/26.
• 2、 Yasuo,Suzuki,Yoneda. "A convenient synthesis of a-substituted cyclic α-imino acids". . p. 1931 - 1934. Retrieved 2007/10/05.