(E)-α-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-2-thiophene propanoic acid acetate

Base Information

• Chemical Name: (E)-α-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-2-thiophene propanoic acid acetate
• CAS No.: 1104528-98-4
• Molecular Formula: C₂H₄O₂*C₂₃H₂₄N₂O₄S
• Molecular Weight: 484.573
• Mol file: 1104528-98-4.mol

Synonyms:(E)-α-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-2-thiophene propanoic acid acetate

Chemical Property of (E)-α-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-2-thiophene propanoic acid acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-α-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-2-thiophene propanoic acid acetate

There total 4 articles about (E)-α-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-2-thiophene propanoic acid acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

eprosartan (133040-01-4,148674-39-9) + acetic acid (64-19-7,77671-22-8) → (E)-α-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-2-thiophene propanoic acid acetate (1104528-98-4)

Guidance literature:

With pyrographite; at 25 - 80 ℃; for 1h;

Reference yield:

2-n-butyl-1-[(4-carbomethoxyphenyl)methyl]-1H-imidazol-5-carboxaldehyde (133040-03-6) → (E)-α-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-2-thiophene propanoic acid acetate (1104528-98-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: piperidine; propionic acid / toluene; hexane / 25 - 70 °C / Reflux

2.1: sodium hydroxide / ethanol; water / 4 - 5 h / 25 - 60 °C

2.2: pH 5

3.1: 25 - 30 °C

With sodium hydroxide; piperidine; propionic acid; In ethanol; hexane; water; toluene;

Reference yield:

3-ethoxy-3-oxo-2-(thien-3-ylmethyl)propanoic acid (143468-96-6) → (E)-α-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-2-thiophene propanoic acid acetate (1104528-98-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: piperidine; propionic acid / toluene; hexane / 25 - 70 °C / Reflux

2.1: sodium hydroxide / ethanol; water / 4 - 5 h / 25 - 60 °C

2.2: pH 5

3.1: 25 - 30 °C

With sodium hydroxide; piperidine; propionic acid; In ethanol; hexane; water; toluene;

upstream raw materials:

eprosartan

acetic acid

2-n-butyl-1-[(4-carbomethoxyphenyl)methyl]-1H-imidazol-5-carboxaldehyde

3-ethoxy-3-oxo-2-(thien-3-ylmethyl)propanoic acid

Downstream raw materials:

eprosartan

Refernces

• 1、 -. "EPROSARTAN MESYLATE CRYSTALLINE PARTICLES AND A PROCESS FOR PREPARING PURE EPROSARTAN". Page/Page column 11. . Retrieved 2009/03/07.