L-BMAA HYDROCHLORIDE

Base Information

• Chemical Name: L-BMAA HYDROCHLORIDE
• CAS No.: 16012-55-8
• Molecular Formula: C4H10 N2 O2 . Cl H
• Molecular Weight: 0
• Hs Code.: 2922499990
• Mol file: 16012-55-8.mol

Synonyms:L-Alanine,3-(methylamino)-, monohydrochloride (9CI)

Chemical Property of L-BMAA HYDROCHLORIDE

Chemical Property:

• PSA: 75.35000
• LogP: 0.51090
• Storage Temp.: −20°C
• Solubility.: H2O: soluble (solutions may be stored for several days at 4°C)

Purity/Quality:

99%, ^*data from raw suppliers

β-Methylamino-L-alanineHydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

Useful:

• Uses: L-BMAA hydrochloride has been used as a standard to compare all the samples in the analysis of β-N-methylamino-l-alanine (BMAA) isomers in desert crust material. It has also been used as an additive with f/2+Si medium?to treat the cells of?Phaeodactylum tricornutum and?Thalassiosira weissflogii?to study its effect on them.

Technology Process of L-BMAA HYDROCHLORIDE

There total 5 articles about L-BMAA HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

β-N-methyl-N-benzylamino alaninate → (S)-2-amino-3-(methylamino)propionic acid hydrochloride (16012-55-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; under 2585.81 Torr;

DOI:10.1016/j.tetlet.2014.02.037

Reference yield:

C28H25Cl2N3NiO4 + methylamine hydrochloride (593-51-1) → (S)-2-amino-3-(methylamino)propionic acid hydrochloride (16012-55-8) + (S)-N-(2-benzoylphenyl)-1-(3,4-dichlorobenzyl)pyrrolidine-2-carboxamide hydrochloride

Guidance literature:

C₂₈H₂₅Cl₂N₃NiO₄; With acetic anhydride; sodium carbonate; In acetonitrile; at 25 - 70 ℃;

methylamine hydrochloride; With potassium carbonate; In acetonitrile; at 50 ℃; for 6h;

With hydrogenchloride; water; In ethanol;

DOI:10.1016/j.tetasy.2010.10.015

Reference yield:

C28H26ClN3NiO4 + methylamine hydrochloride (593-51-1) → (S)-N-(2-benzoylphenyl)-1-(2-chlorobenzyl)pyrrolidine-2-carboxamide hydrochloride (884659-56-7) + (S)-2-amino-3-(methylamino)propionic acid hydrochloride (16012-55-8)

Guidance literature:

C₂₈H₂₆ClN₃NiO₄; With acetic anhydride; sodium carbonate; In acetonitrile; at 25 - 70 ℃;

methylamine hydrochloride; With potassium carbonate; In acetonitrile; at 50 ℃; for 1.5h;

With hydrogenchloride; water; In ethanol;

DOI:10.1016/j.tetasy.2010.10.015

upstream raw materials:

methylamine hydrochloride

Refernces

• 1、 Saghiyan, Ashot S.,Stepanyan, Lala A.,Manasyan, Luiza L.,Geolchanyan, Arpine V.,Djamgaryan, Silva M.,Ajvazyan, Hrant R.,Panosyan, Henry A.,Maleev, Viktor I.,Saveleva, Tatiana F.. "Synthesis of novel chiral NiII complexes of dehydroalanine Schiff bases and their reactivity in asymmetric nucleophilic addition reactions. Novel synthesis of (S)-2-carboxypiperazine". scheme or table. p. 2638 - 2645. Retrieved 2011/02/16.