o-Toluenesulfinic acid, sodium salt

Base Information

• Chemical Name: o-Toluenesulfinic acid, sodium salt
• CAS No.: 15898-37-0
• Molecular Formula: C7H8 O2 S . Na
• Molecular Weight: 178.187
• Hs Code.: 2930909090
• Mol file: 15898-37-0.mol

Synonyms:Benzenesulfinicacid, 2-methyl-, sodium salt (9CI); o-Toluenesulfinic acid, sodium salt(7CI,8CI); Sodium o-methylbenzenesulfinate; Sodium o-toluenesulfinate

Chemical Property of o-Toluenesulfinic acid, sodium salt

Chemical Property:

• PSA: 59.34000
• LogP: 2.09870

Purity/Quality:

98%Min ^*data from raw suppliers

2-METHYLBENEZENESULFINIC ACID SODIUM SALT 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of o-Toluenesulfinic acid, sodium salt

There total 7 articles about o-Toluenesulfinic acid, sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-thiocresol (137-06-4) → sodium 2-methylbenzenesulfinate (15898-37-0)

Guidance literature:

2-thiocresol; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.25h; Inert atmosphere;

With (S,S)-(-)-3-phenyl-2-phenylsulphonyloxaziridine; In tetrahydrofuran; at -50 - 20 ℃; Inert atmosphere;

DOI:10.1002/adsc.201600929

Reference yield: 78.0%

→ sodium 2-methylbenzenesulfinate (15898-37-0)

Guidance literature:

With iron(III) chloride; rongalite; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 0.333333h;

Reference yield: 35.0%

methyl 3-(o-tolylsulfonyl)propanoate → sodium 2-methylbenzenesulfinate (15898-37-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.5h;

DOI:10.1039/d0cc01576h

upstream raw materials:

Toluene-2-sulfonyl chloride

2-Methylphenylboronic acid

2-thiocresol

2-methylbenzenesulfinyl chloride

Downstream raw materials:

1-(benzylsulfonyl)-2-methylbenzene

2-(o-Tolyl)benzonitrile

1-(o-tolylsulfonyl)piperidine

phenyl o-tolyl sulfone

Refernces

• 1、 Chen, Qian,Gao, Yang,Hu, Yifan,Huang, Yuanting,Li, Xianwei,Zhao, Xi. "A three-component reaction of arynes, sodium sulfinates, and aldehydes toward 2-sulfonyl benzyl alcohol derivatives". . p. 7066 - 7073. Retrieved 2021/08/25.
• 2、 Higham, Joe I.,Bull, James A.. "Copper catalysed oxidative α-sulfonylation of branched aldehydes using the acid enhanced reactivity of manganese(iv) oxide". . p. 4587 - 4590. Retrieved 2020/05/05.