beta-Nicotinamide ribose monophosphate

Base Information

• Chemical Name: beta-Nicotinamide ribose monophosphate
• CAS No.: 75414-16-3
• Molecular Formula: C₁₁H₁₆N₂O₈P
• Molecular Weight: 335.23
• DSSTox Substance ID: DTXSID401175036
• Nikkaji Number: J1.476.680D,J9.877I
• Wikipedia: Nicotinamide_mononucleotide
• Wikidata: Q27108984
• Mol file: 75414-16-3.mol

Synonyms:Mononucleotide, Nicotinamide;Nicotinamide Mononucleotide

Chemical Property of beta-Nicotinamide ribose monophosphate

Chemical Property:

• XLogP3: -3.4
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 5
• Exact Mass: 335.06442747
• Heavy Atom Count: 22
• Complexity: 457

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)O)O)O)C(=O)N
• Isomeric SMILES: C1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)O)O)O)C(=O)N
• Recent ClinicalTrials: Safety and Pharmacokinetics of Nicotinamide Mononucleotide (NMN) in Healthy Adults.

Technology Process of beta-Nicotinamide ribose monophosphate

There total 1 articles about beta-Nicotinamide ribose monophosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

nicotinamide adenine dinucleotide (865-05-4) → nicotinamide riboside 5'-monophosphate (75414-16-3) + 5'-adenosine monophosphate (61-19-8,24937-83-5,67583-85-1)

Guidance literature:

With phosphordiesterase I; Enzymatic reaction;

DOI:10.1021/ja910342d

Reference yield: 9.0%

8-oxyadenosine 5'-monophosphate (25030-04-0) + nicotinamide riboside 5'-monophosphate (75414-16-3) → 8-oxy-NAD(+)

Guidance literature:

With pyridine; dicyclohexyl-carbodiimide; In water; at 20 ℃; for 168h;

DOI:10.1039/c0ob00396d

Reference yield:

8-phenyl-adenosine 5'-monophosphate morpholidate (1018828-91-5) + nicotinamide riboside 5'-monophosphate (75414-16-3) → C27H31N7O14P2 (1018828-98-2)

Guidance literature:

With magnesium sulfate; formamide; manganese(ll) chloride; at 20 ℃; for 48h;

DOI:10.1021/jm7010386

upstream raw materials:

nicotinamide adenine dinucleotide

Downstream raw materials:

C₂₇H₃₁N₇O₁₄P₂

C₂₇H₃₁N₇O₁₃P₂

8-bromo-β-nicotinamide adenine dinucleotide

1,4-dihydronicotinamide mononucleotide

Refernces