O-METHOXYCINNAMOYL CHLORIDE

Base Information

• Chemical Name: O-METHOXYCINNAMOYL CHLORIDE
• CAS No.: 15851-91-9
• Molecular Formula: C₁₀H₉ClO₂
• Molecular Weight: 196.633
• Hs Code.: 2918990090
• Mol file: 15851-91-9.mol

Synonyms:Cinnamoylchloride, o-methoxy- (8CI); 2-Methoxycinnamoyl chloride

Chemical Property of O-METHOXYCINNAMOYL CHLORIDE

Chemical Property:

• PSA: 26.30000
• LogP: 2.47380

Purity/Quality:

98%min ^*data from raw suppliers

(2E)-3-(2-methoxyphenyl)acryloylchloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of O-METHOXYCINNAMOYL CHLORIDE

There total 3 articles about O-METHOXYCINNAMOYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-(2'-methoxyphenyl)propenoic acid (6099-03-2) → 2-methoxycinnamoyl chloride (15851-91-9,118652-92-9,118652-93-0)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In benzene; at 10 ℃; for 2h;

Reference yield:

ortho-anisaldehyde (135-02-4) → 2-methoxycinnamoyl chloride (15851-91-9,118652-92-9,118652-93-0)

Guidance literature:

Multi-step reaction with 2 steps

2: oxalyl dichloride / dichloromethane / 0 °C

With oxalyl dichloride; In dichloromethane; 1: Knoevenagel condensation;

DOI:10.1016/j.bmcl.2011.11.078

Reference yield:

→ 2-methoxycinnamoyl chloride (15851-91-9,118652-92-9,118652-93-0)

Guidance literature:

upstream raw materials:

3-(2'-methoxyphenyl)propenoic acid

ortho-anisaldehyde

Downstream raw materials:

(Z)-5-(2-Methoxy-phenyl)-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-pent-4-enoic acid tert-butyl ester

(Z)-5-(2-Methoxy-phenyl)-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-pent-4-enoic acid benzyl ester

N-benzyl-N-(3-oxobutyl)-(E)-3-(2-methoxyphenyl)propenamide

1-[3-(2-methoxy-phenyl)-acryloyl]-4-(4-oxo-5-phenyl-4,5-dihydro-oxazol-2-yl)-piperazine

Refernces

• 1、 Malbari, Khushboo,Saha, Priyanka,Chawla-Sarkar, Mamta,Dutta, Shanta,Rai, Swita,Joshi, Mamata,Kanyalkar, Meena. "In quest of small-molecules as potent non-competitive inhibitors against influenza". . . Retrieved 2021/07/19.
• 2、 -. "Isoalantolactone derivative, pharmaceutical composition and application thereof". Paragraph 0014. . Retrieved 2019/02/02.