2,6-Lutidinehydrochloride

Base Information

• Chemical Name: 2,6-Lutidinehydrochloride
• CAS No.: 15439-85-7
• Molecular Formula: C7H9 N . Cl H
• Molecular Weight: 143.616
• Mol file: 15439-85-7.mol

Synonyms:2,6-Lutidine,hydrochloride (8CI); Pyridine, 2,6-dimethyl-, hydrochloride (9CI);2,6-Dimethylpyridine hydrochloride; 2,6-Dimethylpyridinium chloride;2,6-Dimethylpyridinium monohydrochloride; 2,6-Lutidinium chloride

Chemical Property of 2,6-Lutidinehydrochloride

Chemical Property:

• PSA: 12.89000
• LogP: 2.50040

Purity/Quality:

99%min ^*data from raw suppliers

2,6-LUTIDINE HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-Lutidinehydrochloride

There total 7 articles about 2,6-Lutidinehydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,6-dimethylpyridine (108-48-5) → 2,6-lutidine hydrochloride (15439-85-7)

Guidance literature:

With hydrogenchloride; In diethyl ether; hexane; at 0 ℃; Inert atmosphere;

DOI:10.1021/acs.inorgchem.6b02959

Reference yield:

2,6-dimethylpyridine (108-48-5) + benzoyl chloride (98-88-4) → 2,6-lutidine hydrochloride (15439-85-7) + benzoic acid (65-85-0,8013-63-6)

Guidance literature:

With water; In 1,4-dioxane; at 25 ℃; Concentration; Kinetics;

DOI:10.14233/ajchem.2013.14238

Reference yield:

2,6-dimethylpyridine (108-48-5) + 4-chloro-benzoyl chloride (122-01-0) + ethyl (3R,S)-2,2-difluoro-3-hydroxy-(2,2-dimethyldioxolpent-4-yl)propionate (928797-50-6,166376-97-2) → ethyl 3-(4-chlorobenzoyloxy)-2,2-difluoro-3-(2,2-dimethyldioxolan-4-yl)-propionate + ethyl 3-(4-chlorobenzoyloxy)-2,2-difluoro-3-(2,2-dimethyldioxolan-4-yl)-propionate + 2,6-lutidine hydrochloride (15439-85-7)

Guidance literature:

With dmap; In ethyl acetate; at 65 - 70 ℃; for 4h;

upstream raw materials:

2,6-dimethylpyridine

vinylsulfonyl chloride

4-chloro-benzoyl chloride

ethyl (3R,S)-2,2-difluoro-3-hydroxy-(2,2-dimethyldioxolpent-4-yl)propionate

Downstream raw materials:

(2,2',2''-tris(phenylphenylamino)triethylamine)MoCl

Mo(C₆H₁₂N(NC₆H₅)3)Cl

Mo(C₆H₁₂N(NC₆H₃(CH₃)2)3)Cl

[2,6-Me₂C₅H₃NH+] [H₃CB(C₆F₅)3-]

Refernces

• 1、 Fasano, Valerio,Curless, Liam D.,Radcliffe, James E.,Ingleson, Michael J.. "Frustrated Lewis Pair Mediated 1,2-Hydrocarbation of Alkynes". supporting information. p. 9202 - 9206. Retrieved 2017/07/25.
• 2、 Haack, Peter,Kaergel, Anne,Greco, Claudio,Dokic, Jadranka,Braun, Beatrice,Pfaff, Florian F.,Mebs, Stefan,Ray, Kallol,Limberg, Christian. "Access to a CuII-O-CuII motif: Spectroscopic properties, solution structure, and reactivity". supporting information. p. 16148 - 16160. Retrieved 2013/11/19.