(4-aminophenyl)biphenyl-4-ylmethanone

Base Information

• Chemical Name: (4-aminophenyl)biphenyl-4-ylmethanone
• CAS No.: 71969-47-6
• Molecular Formula: C₁₉H₁₅NO
• Molecular Weight: 273.334
• Mol file: 71969-47-6.mol

Synonyms:(4-aminophenyl)biphenyl-4-ylmethanone

Chemical Property of (4-aminophenyl)biphenyl-4-ylmethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-aminophenyl)biphenyl-4-ylmethanone

There total 2 articles about (4-aminophenyl)biphenyl-4-ylmethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

biphenyl (92-52-4,1594-86-1) + 4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → (4-aminophenyl)biphenyl-4-ylmethanone (71969-47-6)

Guidance literature:

biphenyl; 4-amino-benzoic acid; In dichloromethane; at 80 - 190 ℃; for 3h;

With ammonia; In dichloromethane; water;

DOI:10.1016/j.ejmech.2009.12.070

Reference yield:

[1,1'-biphenyl]-4-yl(4-nitrophenyl)methanone (6317-76-6) → (4-aminophenyl)biphenyl-4-ylmethanone (71969-47-6)

Guidance literature:

With hydrogenchloride; acetic acid; tin(ll) chloride;

Reference yield:

(4-aminophenyl)biphenyl-4-ylmethanone (71969-47-6) → acetoxy-(4-acetylamino-phenyl)-biphenyl-4-yl-methane

Guidance literature:

Multi-step reaction with 2 steps

1: zinc; methanol. NaOH-solution

2: sodium acetate

With sodium hydroxide; sodium acetate; zinc;

upstream raw materials:

[1,1'-biphenyl]-4-yl(4-nitrophenyl)methanone

biphenyl

4-amino-benzoic acid

Downstream raw materials:

C₃₂H₂₆N₄

Refernces

• 1、 Abu Khalaf, Reema,Abu Sheikha, Ghassan,Bustanji, Yasser,Taha, Mutasem O.. "Discovery of new cholesteryl ester transfer protein inhibitors via ligand-based pharmacophore modeling and QSAR analysis followed by synthetic exploration". experimental part. p. 1598 - 1617. Retrieved 2010/06/12.